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Fig. 1 | Journal of Ovarian Research

Fig. 1

From: WISP1 induces ovarian cancer via the IGF1/αvβ3/Wnt axis

Fig. 1

IGF1 expression is elevated in ovarian cancer, which is related to the dismal prognosis of ovarian cancer patients. A IGF1 expression in adjacent normal tissues and ovarian cancer tissues analyzed using GEPIA website (* p < 0.05 vs. adjacent normal tissues). The abscissa OV represents ovarian cancer, T represents tumor tissue samples (red box), and N represents adjacent normal tissue samples (gray box). B Relationship between IGF1 expression and prognosis of ovarian cancer patients analyzed using UALCAN website. C The relationship between IGF1 expression and tumor grade of patients with ovarian cancer analyzed using UALCAN website (** p < 0.01, **** p < 0.0001). D IGF1 expression in ovarian cancer tissues and adjacent normal tissues determined by RT-qPCR (n = 57; **** p < 0.0001, vs. adjacent normal tissues). E IGF1 expression in ovarian cancer tissues and adjacent normal tissues determined by IHC (n = 57; **** p < 0.0001, vs. adjacent normal tissues). F Venn diagram of IGF1 related genes and tumor metastasis-related genes analyzed by UALCAN website, followed by intersection. Blue circles represent 389 genes associated with IGF1 expression, and red circles represent 146 tumor metastasis-related genes. G GO and KEGG enrichment analysis of key genes performed by ClueGO (According to KappaScore, they were divided into five groups and expressed in five different colors). Data comparisons between adjacent normal tissues and ovarian cancer tissues were analyzed by paired t-test

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