Fig. 1

Presence of senescent, SA-β-Gal-marked ovarian cancer cells in tumors in vivo. Quantification of senescent cancer cell frequency in tumors from chemotherapy-naïve patients and from patients treated with CPT + PCT before cytoreduction (A). Determination of SA-β-Gal staining area in cancerous tissue within tumors from patients displaying signs of cellular senescence (B). Representative pictures demonstrating green SA-β-Gal staining in both groups of patients (C). The measurements were performed using tumors obtained from 30 different patients per group. The results depicted on panel B are expressed as the means ± SEM. ** p < 0.01 vs. No drugs. Magnification × 400; bar = 50 μm