Fig. 2

Effect of senescent pEOCs secretome on ovarian cancer cell progression in vitro. Analysis of pEOCs-derived conditioned medium effect on adhesion (to PMCs – A and to PFBs—B) proliferation (C), migration (D), and invasion (D) of non-senescent ovarian cancer cells. Quantification of occludin (F) and vimentin (G) expression as markers of EMT. Results derive from 6–8 independent experiments with pEOCs obtained from different donors. The results are expressed as the means ± SEM. * p < 0.05; ** p < 0.01 vs. “Young in vitro” cells; ^# p < 0.05 vs. “Sen in vitro” cells; ^Ψ p < 0.05 vs. “Young/CPT + PCT in vivo” cells. RFU – Relative Fluorescence Units