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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

Fig. 4

Paracrine effects of senescent pEOCs on senescence and pro-cancerogenic activity of normal PMCs (A-D) and PFBs (EH). Quantification of SA-β-Gal activity in PMCs and PFBs exposed to pEOCs-derived conditioned medium (A, E). Proliferation (B, F), migration (C, G), and invasion (D, H) of non-senescent ovarian cancer cells in response to autologous PMCs- and PFBs-derived conditioned medium upon their preexposure to conditioned medium generated by young and senescent pEOCs. The experiments were performed using pooled PMCs and PFBs from 6 different donors and ovarian cancer cells from 6 different patients. The results are expressed as mean ± SEM. The results are expressed as the means ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. “Young” cells; # p < 0.05 vs. “Sen” cells. RFU – Relative Fluorescence Units

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