Table 2 Senescence-associated secretory phenotype in pEOCs undergoing spontaneous and drug-induced senescence in vitro and in vivo

Angiogenesis

ANG1 (pg/10⁵ cells)

654 ± 316

5787 ± 1171^a

2353 ± 356^a*

1510 ± 343^a

3186 ± 631^b*

bFGF (pg/10⁵ cells)

6 ± 1

44 ± 5^a

49 ± 5^a

5 ± 1

30 ± 8^b

CXCL8/IL-8 (pg/10⁵ cells)

129 ± 48

613 ± 54^a

748 ± 142^a

138 ± 61

414 ± 134^b*

FGF5 (fg/10⁵ cells)

839 ± 98

7034 ± 181^a

2873 ± 89^a*

1554 ± 163^a

4982 ± 212^b*

VEGF (pg/10⁵ cells)

89 ± 18

228 ± 42^a

132 ± 22^a*

91 ± 35

283 ± 48^b

ECM remodeling and invasion

ADAM12 (pg/10⁵ cells)

254 ± 63

2330 ± 562^a

646 ± 81^a*

802 ± 348^a

1496 ± 255^b*

PDGF-D (fg/10⁵ cells)

625 ± 134

6695 ± 1354^a

2411 ± 771^a*

762 ± 235

4485 ± 622^b*

tPA (pg/10⁵ cells)

41 ± 9

343 ± 53^a

282 ± 19 ^a*

118 ± 26^a

169 ± 13 ^b*

TGF-β1 (pg/10⁵ cells)

19 ± 6

107 ± 33^a

29 ± 3*

12 ± 4

31 ± 9 ^b*

TIMP-1 (pg/10⁵ cells)

473 ± 127

3802 ± 592^a

1613 ± 304^a*

858 ± 346^a

2702 ± 369^b*

TSP-1 (ng/10⁵ cells)

11 ± 2

93 ± 11^a

39 ± 5^a*

21 ± 4^a

69 ± 8^b*

uPA (pg/10⁵ cells)

33 ± 9

104 ± 25^a

78 ± 20

24 ± 4

104 ± 11^b

Inflammation

CCL2/MCP-1 (pg/10⁵ cells)

130 ± 37

1131 ± 230^a

470 ± 57^a*

273 ± 28^a

776 ± 90^b*

ICAM-1 (pg/10⁵ cells)

256 ± 48

830 ± 143^a

607 ± 80^a*

241 ± 38

694 ± 135

IL-6 (pg/10⁵ cells)

25 ± 6

482 ± 154^a

119 ± 7^a*

65 ± 15^a

449 ± 33^b

VCAM-1 (pg/10⁵ cells)

64 ± 16

285 ± 76^a

144 ± 30^a*

107 ± 25^a

275 ± 63

Proliferation and migration

CCL11 (pg/10⁵ cells)

45 ± 12

364 ± 69^a

148 ± 26^a*

80 ± 33^a

254 ± 32^b

CXCL1/GRO-1 (pg/10⁵ cells)

75 ± 11

497 ± 100^a

572 ± 143^a

204 ± 111^a

532 ± 88^b

CXCL12/SDF-1 (pg/10⁵ cells)

2 ± 1

14 ± 5^a

5 ± 1^a*

3 ± 1

9 ± 2^b

CXCL5 (pg/10⁵ cells)

16 ± 4

37 ± 11^a

149 ± 24^a*

31 ± 7^a

43 ± 15

EGF (fg/10⁵ cells)

744 ± 23

4268 ± 199^a

2831 ± 508^a*

3175 ± 757^a

5002 ± 449^b

HGF (pg/10⁵ cells)

30 ± 6

239 ± 22^a

54 ± 14*

15 ± 3^a

59 ± 6^b*

IGF-1 (pg/10⁵ cells)

15 ± 5

124 ± 28^a

37 ± 3^a*

12 ± 6

616 ± 179^b*

NRP-1 (pg/10⁵ cells)

62 ± 18

494 ± 86^a

206 ± 34^a*

114 ± 47^a

358 ± 50^b