Table 3 Secretory phenotype of peritoneal mesothelial cells subjected to a conditioned medium generated by young and senescent ovarian cancer cells

Angiogenesis

ANG1 (pg/10⁵ cells)

87 ± 8

245 ± 12^a

192 ± 10^a*

CXCL8/IL-8 (pg/10⁵ cells)

53 ± 4

104 ± 6^a

79 ± 2^a*

FGF5 (pg/10⁵ cells)

18 ± 3

41 ± 3^a

43 ± 3^a

VEGF (pg/10⁵ cells)

66 ± 1

579 ± 50^a

351 ± 29^a*

ECM remodeling and invasion

ADAM12 (pg/10⁵ cells)

12 ± 1

46 ± 7^a

39 ± 4^a

PDGF-D (fg/10⁵ cells)

46 ± 5

173 ± 17^a

122 ± 4^a*

tPA (pg/10⁵ cells)

7 ± 1

38 ± 4^a

20 ± 2 ^a*

TGF-β1 (pg/10⁵ cells)

61 ± 5

366 ± 32^a

261 ± 17^a*

TIMP-1 (pg/10⁵ cells)

69 ± 3

193 ± 12^a

185 ± 10^a

uPA (pg/10⁵ cells)

18 ± 1

50 ± 2^a

48 ± 4^a

Inflammation

CCL2/MCP-1 (pg/10⁵ cells)

16 ± 1

60 ± 13^a

75 ± 7^a

ICAM-1 (pg/10⁵ cells)

7 ± 1

38 ± 5^a

35 ± 2^a

IL-6 (pg/10⁵ cells)

65 ± 4

463 ± 44^a

274 ± 5^a*

VCAM-1 (pg/10⁵ cells)

46 ± 2

104 ± 10^a

76 ± 7^a*

Proliferation and migration

CCL11 (pg/10⁵ cells)

4 ± 1

13 ± 1^a

12 ± 1^a

CXCL1/GRO-1 (pg/10⁵ cells)

16 ± 1

75 ± 7^a

64 ± 9^a

CXCL12/SDF-1 (pg/10⁵ cells)

83 ± 5

101 ± 5^a

178 ± 8^a*

IGF-1 (pg/10⁵ cells)

10 ± 1

45 ± 5^a

47 ± 7^a

NRP-1 (pg/10⁵ cells)

72 ± 5

112 ± 16^a

184 ± 2^a*