Table 4 Secretory phenotype of peritoneal fibroblasts subjected to conditioned medium generated by young and senescent ovarian cancer cells

Angiogenesis

ANG1 (pg/10⁵ cells)

46 ± 13

301 ± 17^a

140 ± 7^a*

CXCL8/IL-8 (pg/10⁵ cells)

120 ± 4

274 ± 26^a

231 ± 10^a

FGF5 (pg/10⁵ cells)

43 ± 8

58 ± 9

53 ± 4

VEGF (pg/10⁵ cells)

27 ± 2

37 ± 5^a

44 ± 6^a

ECM remodeling and invasion

ADAM12 (pg/10⁵ cells)

52 ± 3

76 ± 2^a

54 ± 2*

PDGF-D (fg/10⁵ cells)

174 ± 16

252 ± 23^a

222 ± 20^a

tPA (pg/10⁵ cells)

18 ± 1

50 ± 4^a

49 ± 7^a

TGF-β1 (pg/10⁵ cells)

22 ± 4

52 ± 5^a

45 ± 2^a

TIMP-1 (pg/10⁵ cells)

149 ± 5

250 ± 8^a

165 ± 5^a*

uPA (pg/10⁵ cells)

41 ± 1

77 ± 4^a

49 ± 4*

Inflammation

CCL2/MCP-1 (pg/10⁵ cells)

75 ± 6

117 ± 18^a

77 ± 7^a*

ICAM-1 (pg/10⁵ cells)

15 ± 2

64 ± 3^a

39 ± 2^a*

IL-6 (pg/10⁵ cells)

50 ± 8

742 ± 82^a

246 ± 14^a*

VCAM-1 (pg/10⁵ cells)

104 ± 4

220 ± 17^a

114 ± 9^a*

Proliferation and migration

CCL11 (pg/10⁵ cells)

8 ± 2

11 ± 2

9 ± 3

CXCL1/GRO-1 (pg/10⁵ cells)

110 ± 3

186 ± 14^a

121 ± 11*

CXCL12/SDF-1 (pg/10⁵ cells)

99 ± 3

184 ± 9^a

120 ± 8^a*

IGF-1 (pg/10⁵ cells)

33 ± 4

56 ± 6^a

41 ± 2^a*

NRP-1 (pg/10⁵ cells)

40 ± 6

371 ± 41^a

66 ± 3^a*