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Table 5 Expression of mRNA for genes associated with drug-resistance in young and senescent pEOCs

From: Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

Gene

No drugs (spontaneous)

CPT + PCT in vitro

 

young

senescent

senescent

ABCB1/MDR1

1.4 ± 0.4

1.8 ± 0.7

1.3 ± 0.7

ABCC4

1.2 ± 0.3

1.1 ± 0.6

1.4 ± 0.6

AKT1

1.1 ± 0.2

1.9 ± 0.9

1.6 ± 0.7

PLK2

1.2 ± 0.3

2.8 ± 1.4

1.3 ± 0.6

BIRC5/Survivin

1.2 ± 0.3

0.9 ± 0.3

1.2 ± 0.5

CHEK1

1.7 ± 0.8

2.1 ± 1.0

1.2 ± 0.7

CHEK2

1.8 ± 0.8

2.2 ± 1.5

1.0 ± 0.4

PHB1/Prohibitin-1

2.5 ± 1.2

1.9 ± 0.9

2.8 ± 2.2

PHB2/Prohibitin-2

1.4 ± 0.5

1.0 ± 0.5

1.0 ± 0.6

CCND1/cyclin D1

1.1 ± 0.3

2.2 ± 1.0

1.0 ± 0.6

  1. Experiments were performed using pEOCs obtained from 6 different patients. Each sample was tested in duplicate. The results are expressed as mean ± SEM. Expression of mRNA for β-actin was used as the reference
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Journal of Ovarian Research

ISSN: 1757-2215

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