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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Hexokinase 2 promoted cell motility and proliferation by activating Akt1/p-Akt1 in human ovarian cancer cells

Fig. 2

HK2 elevated the expression of EMT-related proteins in human ovarian cancer cells. The mRNA expression of Fibronectin, MMP9, CDH2, Vemintin, ZEB1, ZEB2 was detected by real-time quantitative PCR, and the quantitative analysis is shown: (A) SKOV3-GFP and SKOV3-HK2; (B) A2780-shCtr and A2780-shHK2. The protein level of Fibronectin, MMP9, CDH2, Vemintin, ZEB1, ZEB2 was detected by western blot: (C) SKOV3-GFP and SKOV3-HK2; (D) A2780-shCtr and A2780-shHK2, and the quantitative analysis is shown: (E) SKOV3-GFP and SKOV3-HK2; (F) A2780-shCtr and A2780-shHK2. G The positive correlation between HK2 and Fibronectin, MMP9, CDH2, Vemintin, ZEB1, ZEB2 expression in ovarian serous cystadenocarcinoma were confirmed from the GEPIA online database. The data are shown as the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01 vs. control using one-way ANOVA

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