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Table 4 Subgroup analyses (categorized relative to the age of 40 years) of POSEIDIN Group 4 patients with AOA or non-AOA

From: Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles

 

<  40 (35 ~ 39) y/o

 

40 (40 ~ 45) y/o

 

Parameters

AOA

(n = 32)

Non-AOA

(n = 68)

P value

AOA

(n = 59)

Non-AOA

(n = 100)

P value

Age (years)

37.8 ± 1.5

37.5 ± 1.3

0.378

42.6 ± 1.6

42.3 ± 1.4

0.240

Body mass index (kg/m2)

22.4 ± 3.0

23.1 ± 3.0

0.263

23.5 ± 4.2

23.5 ± 3.7

0.889

Antral follicle counts (n)

5.9 ± 2.6

7.8 ± 3.6

0.012

6.5 ± 3.2

6.3 ± 3.5

0.794

Anti-Müllerian hormone (ng/ml)

0.50 ± 0.30

0.72 ± 0.29

0.001

0.61 ± 0.33

0.63 ± 0.34

0.728

No. of oocytes retrieved (n)

3.3 ± 2.1

5.0 ± 3.1

0.008

4.5 ± 2.8

4.1 ± 2.9

0.394

No. of metaphase II oocytes (n)

2.6 ± 1.8

4.0 ± 2.5

0.007

3.5 ± 2.2

3.4 ± 2.4

0.833

Maturation rate (%)

81.3 ± 21.8

82.3 ± 17.6

0.808

80.4 ± 20.4

82.0 ± 20.5

0.626

No. of fertilized oocytes (n)

2.3 ± 1.7

3.4 ± 2.3

0.024

3.0 ± 1.9

2.8 ± 2.0

0.618

Fertilization rate (%)

86.9 ± 23.5

82.5 ± 24.8

0.403

85.8 ± 24.6

83.4 ± 26.8

0.575

No. of Day 3 embryos (n)

2.2 ± 1.5

3.0 ± 2.3

0.084

2.8 ± 1.6

2.6 ± 2.0

0.547

Cleavage rate (%)

92.2 ± 20.8

86.3 ± 20.6

0.200

96.3 ± 31.3

86.6 ± 24.3

0.035

No. of top-quality Day 3 embryos (n)

1.2 ± 1.4

1.3 ± 1.6

0.604

1.5 ± 1.2

1.2 ± 1.4

0.120

1 top-quality Day 3 embryos

64.5%

58.5%

0.571

78.9%

53.7%

0.002

Top-quality Day 3 embryos rate (%)

46.5 ± 41.5

37.1 ± 37.0

0.267

56.8 ± 37.7

34.6 ± 37.7

0.001

Top-quality Day 3 embryos rate50

51.6%

44.6%

0.521

64.9%

41.1%

0.004

  1. Data are presented as the mean ± standard deviation and % (n)
  2. AOA Artificial oocyte activation