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Table 1 Characteristics of included studies

From: Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Author/year

published

Country

POI

Control

Outcome measurements

Matched variables

Number of

cases

Age

of cases

BMI

FSH

E2

Number of

controls

Age

BMI

AbdulAzeez 2018 [14]

Nigeria

50

26.4 ± 5.2

Not reported

23.0 ± 15.0

101.8 ± 42.3

40

26.4 ± 5.4

Not reported

TC, TG, HDL, LDL

Age

Ağaçayak 2016 [15]

Turkey

30

28.9 ± 6.8

24.1 ± 4.2

60 ± 20

17.0 ± 7.2

30

29.2 ± 5.0

23.2 ± 3.3

FG, TC, TG

Age, ethnic

Ates 2014 [16]

Turkey

56

35.23 ± 4.58

25.79 ± 4.10

75.33 ± 39.73

47.44 ± 49.48

59

35.47 ± 4.49

26.09 ± 3.80

WC, SBP, DBP, TC, TG, HDL, LDL, FG, INS

Age

Bozkaya 2020 [17]

Turkey

34

30.94 ± 5.58

25.90 ± 4.22

56.68 ± 28.84

32.32 ± 34.70

35

28.53 ± 5.09

24.47 ± 3.89

SBP, DBP, FG, TC, TG, HDL, LDL

 

Cekici 2021 [18]

Turkey

66

32.5 ± 4.7

23.6 ± 4.3

75.1 ± 34.9

5.4 ± 1.4

73

31.0 ± 4.9

22.7 ± 5.3

FG, TC, TG, HDL, LDL

Age

Czyzyk 2017 [19]

Poland

23

31 ± 7

24.37 ± 4.35

95.29 ± 48.36

29.26 ± 31.29

18

31 ± 3

24.44 ± 3.18

INS, FG, TC, TG, HDL, LDL

Age, BMI

Daan 2017 [20]

Netherland

83

49.9 ± 4.7

25.1 ± 4.1

NA

5.01 [358.49]

267

50.9 ± 3.1

26.9 ± 4.9

WC, SBP, DBP, TC, HDL, LDL

 

Goldmeier 2014 [21]

Brazil

17

37 ± 9

26 ± 5

53.9 ± 24.15

17.7 ± 14.9

15

38 ± 9

26 ± 3

WC, FG, TG, LDL, HDL, TC

Age

Gulhan 2012 [22]

Turkey

47

36.8 ± 1.8

25.9 ± 4.9

94.9 ± 36.4

27.9 ± 28.3

60

36.0 ± 2.3

24.8 ± 4.6

TC, TG, HDL, LDL

Age

Huang 2021 [23]

China

303

34.78 ± 5.42

21.44 ± 2.75

73.23 (51.19 92.85)

7.64 (5.00 28.10)

303

34.68 ± 4.80

21.25 ± 2.92

TC, TG, HDL, LDL, FG

Age

Kalantaridou 2004 [24]

Greece

18

35.4 ± 5.5

24.2 ± 3.1

78.9 ± 22.9

37 ± 24

20

35.0 ± 3.6

23.0 ± 2.6

SBP, DBP, FG, TC, TG, HDL, LDL

Age, BMI

Knauff 2008 [25]

Netherland

90

33.8 ± 5.6

24.9 ± 4.3

79.5 ± 42.3

38.14 ± 41.41

198

30.3 ± 2.9

24.3 ± 4.8

WC, TC, TG, HDL, LDL

 

Kulaksizoglu 2013 [26]

Turkey

43

36.83 ± 2.72

30.33 ± 5.59

48.55 ± 16.63

12.62 ± 9.13

33

37.15 ± 1.88

29.62 ± 3.48

FG, INS, TC, TG, HDL, LDL

 

Kunicki 2018 [27]

Poland

98

31.48 ± 6.07

23.78 ± 3.563

69.71 ± 25.43

22.34 ± 31.69

78

27.78 ± 5.25

22.20 ± 2.94

INS

 

Luo 2018 [28]

China

240

31.58 ± 6.83

21.11 ± 2.57

92.24 ± 33.76

20.46 ± 9.97

240

31.32 ± 6.62

20.90 ± 2.38

WC

Age, BMI

Podfigurna 2018 [29]

Poland

56

30.7 ± 6.9

23.54 ± 4.55

97.57 ± 42.30

21.45 ± 43.07

68

27.3 ± 4.5

28.62 ± 5.30

SBP, DBP, FG, INS, TC, TG, HDL, LDL

Age, weight

Podfigurna 2020 [30]

Poland

132

31.86 ± 7.75

23.68 ± 4.42

100.14 ± 36.93

13.43 ± 18.91

17

23.21 ± 5.86

20.71 ± 5.15

FG, INS

Age, weight

Szlendak-Sauer 2016 [31]

Poland

98

30 ± 6.3

23.5 ± 2.8

73.9 ± 26.8

14.5 ± 8.4

75

29.4 ± 4

23.2 ± 2.5

INS, FG

 

Tunc 2017 [32]

Turkey

30

28.9 ± 6.8

25.9 ± 4.1

60.09 ± 20.01

33.75 ± 39.70

30

29.2 ± 5.0

24.1 ± 4.2

TC, TG, FG

Age, gravidity, BMI

Xu 2019 [33]

China

33

Not reported

Not reported

59.56 ± 32.67

Not reported

72

Not reported

Not reported

TC

 

Yorgun 2012 [34]

Turkey

26

37.5 ± 10.1

26.0 ± 3.6

47.9 ± 17.5

25.0 ± 15.6

31

37.5 ± 9.0

23.3 ± 1.3

SBP, DBP, TC, TG, LDL, HDL, FG

Age

  1. The data are presented as mean ± standard deviation, median (quartile1, quartile 3) and median [range]
  2. BMI Body mass index, FSH Follicle-stimulating hormone, E2 Estradiol, WC Waist circumference, FG Fasting blood glucose, INS Insulin, SBP Systolic blood pressure, DBP Diastolic blood pressure, TC Total cholesterol, HDL High-density lipoprotein, LDL Low-density lipoprotein and TG Triglycerides