Fig. 4
Effects of XAR™ and chemotherapy treatment on pluripotent transcripts in adult gonads. Differential expression of transcript levels in (A) ovary and (B) testes was seen on treatment with XAR™, Bu-Cy and Bu. Compared to control, mice treated with XAR™ showed significant increase in expression of Oct-4A, Sox-2, Nanog, Stella, and Fragilis transcripts, both in ovaries and testis. Two-way ANOVA was used for statistical analysis, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05