Fig. 5From: RETRACTED ARTICLE: Extremely Active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testesEffect of chemoablation and XAR™ treatment on transcripts in ovary. XAR™ treatment in chemoablated mice led to significant increase in expression of transcripts specific to (A) pluripotent cell – Oct-4A, Sox-2, Nanog, primordial germ cell – Stella, Fragilis, (B) progenitor OSCs – total Oct-4, Sca1, pre-meiotic germ cells – Mvh, Stra-8, oocytes – Nobox, Hoxa-10, (C) Fshr – Fshr1, Fshr3, meiotic – Scp3, Dmc1, proliferation (Pcna), (D) maintaining redox potential – Sirt1, Sirt6, p53, and Nampt. The findings are suggestive of XAR™ treatment reinstating neo-oogenesis from VSELs and OSCs in ovary. One-way ANOVA was used for statistical analysis of curative control vs curative treatment and preventive control vs preventive treatment group, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05Back to article page