Fig. 8

Effect of chemotherapy and XAR™ treatment on antioxidant indices (A) GSH (B) MDA and (C) SOD in testis and ovaries. The curative and preventive groups treated with chemotherapy—Busulfan-Cyclophosphamide in female mice and Busulfan in male mice, led to decreased GSH, SOD levels and increased MDA levels. However, XAR™ treatment led to increased GSH, SOD levels and decreased MDA levels. In addition, the antioxidant indices increased in chemoablated XAR™ treated curative and preventive group, indicating increased tissue healing in oxidative damage. Two-way ANOVA was used for statistical analysis, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05