Fig. 2

Different OC cell lines display heterogeneous biosensor responses at baseline and in response to OCM. A Baseline oxidative stress was evaluated in 15 OC cell lines transfected with HyPer-DAAO and HyPer. Scale bars indicate 100 um. B Oxidative stress in HyPer-expressing cell lines was measured using fluorimetry (excitation at 420 and 480 nm) and a comparative analysis was performed. A baseline average of measurements across cell lines was used for normalization. C HyPer signal was quantified after 48 hours of growth in OCM or regular media and normalized to control, regular media-treated cells