Fig. 7

An illustrated model of follicle loss (or burnout) in GalTKO mice compared to WT. In GalTKO ovaries, early mass activation of primordial follicles leads to increased primary follicles and more atretic secondary follicles. Some follicles do achieve preovulatory status; however, as the ovary ages, fewer primordial follicles are available for growth activation. Thus, ovarian aging is accelerated and results in POI