Fig. 1From: Clinical application of PARP inhibitors in ovarian cancer: from molecular mechanisms to the current status[The concept of synthetic lethality and its application in ovarian cancer] Synthetic lethality is defined as a combination of mutations in two or more separate genes that lead to cell death. For example, if a cell suffers the mutation of either gene A or B alone, it can still survive, while mutation of both gene A and B will lead to cell deathBack to article page