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Table 4 Singleton perinatal outcomes of patients in different endometrial preparation protocols

From: Which endometrial preparation protocol provides better pregnancy and perinatal outcomes for endometriosis patients in frozen-thawed embryo transfer cycles? A retrospective study on 1413 patients

Variable

HRT vs. NC

GnRHa + HRT vs. NC

GnRHa + HRT vs. HRT

Crude OR (95% CI)

Adjusted OR (95% CI)

Crude OR (95% CI)

Adjusted OR (95% CI)

Crude OR (95% CI)

Adjusted OR (95% CI)

Delivery mode

1.18 (0.43-3.25)

1.30 (0.47-3.61)

1.34 (0.45-3.98)

1.50 (0.50-4.49)

1.13 (0.62-2.07)

1.15 (0.63-2.11)

Low birth weight < 2500 ga

0.93 (0.21-4.22)

2.12 (0.38-11.95)

1.03 (0.21-5.05)

1.45 (0.24-8.63)

1.11 (0.49-2.51)

0.68 (0.28-1.68)

Macrosomia > 4000 gb

1.83 (0.24-14.17)

1.74 (0.22-13.77)

1.15 (0.13-10.23)

1.14 (0.13-10.33)

0.63 (0.23-1.74)

0.66 (0.24-1.82)

Small for gestational agec, n (%)

0.39 (0.12-1.23)

0.42 (0.13-1.37)

0.54 (0.16-1.85)

0.48 (0.14-1.69)

1.39 (0.62-3.12)

1.14 (0.50-2.62)

Large for gestational aged, n (%)

1.01 (0.37-2.77)

0.97 (0.35-2.69)

0.95 (0.33-2.78)

1.10 (0.37-3.26)

0.94 (0.54-1.64)

1.13 (0.64-2.01)

Preterm birth < 37 wke, n (%)

0.90 (0.30-2.73)

0.68 (0.22-2.16)

0.90 (0.28-2.93)

0.68 (0.20-2.31)

1.00 (0.54-1.88)

0.99 (0.51-1.92)

Gestational diabetes mellitusf, n (%)

0.57 (0.16-2.05)

0.67 (0.18-2.51)

0.28 (0.06-1.34)

0.27 (0.05-1.31)

0.50 (0.17-1.51)

0.40 (0.13-1.23)

Hypertensive disorders of pregnancyg, n (%)

1.30 (0.16-10.25)

1.47 (0.17-12.78)

1.39 (0.16-12.00)

1.65 (0.17-15.87)

1.07 (0.40-2.89)

1.12 (0.39-3.22)

Fetal malformationh, n (%)

1.09 (0.14-8.74)

0.96 (0.12-7.88)

0.45 (0.04-5.13)

0.41 (0.04-4.78)

0.41 (0.09-1.89)

0.43 (0.09-1.97)

  1. Odds ratios (ORs) and 95% confidence intervals (CIs) are based on the univariate analysis while adjusted odds ratios (AORs) and 95% CIs are based on the multiple logistic regression model
  2. a Adjusted for maternal age at FET, BMI, AMH, duration of infertility, No. of oocytes retrieved, No. of MII oocytes, endometrial thickness,No. of embryos transferred
  3. b Adjusted for maternal age at FET, BMI, interval between FET and IVF/ICSI
  4. c Adjusted for maternal age at FET, BMI, No. of MII oocytes
  5. d Adjusted for maternal age at FET, BMI, AFC and unexplained/other ovarian stimulation protocols
  6. e Adjusted for maternal age at FET, BMI, ovarian stimulation protocols, normal fertilization rate, and type of embryo transferred
  7. f Adjusted for maternal age at FET, BMI, No. of MII oocytes
  8. g Adjusted for maternal age at FET, BMI,diminished ovarian reserve, normal fertilization rate, and endometrial thickness
  9. h Adjusted for maternal age at FET, BMI and FSH