Fig. 2From: Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variantsPrevalence of candidate gene variants identified in POI patients. The 61 pathogenic/likely pathogenic filtered variants were located in 19 genes, including 6 meiosis genes, 6 transcription factors, and 7 genes involved in steroid hormone synthesis or response pathways. Among these, the transcription factors had the highest mutation frequency (7.2%), followed by steroid hormone synthesis or receptor genes (6.2%) and meiotic genes (2.0%)Back to article page