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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants

Fig. 4

POI pedigrees harboring compound heterozygous variants or multigenic variants. The probands are marked with arrows, women with POI are depicted by black circles, and healthy women are depicted by white circles and healthy men by white squares. a In pedigree F254, the proband and her sister carried the compound heterozygous variation NOBOX p.L558fs and p.R355H, which was inherited from their father and mother separately. b In pedigree F191, proband POI-63 carried compound heterozygous mutation MSH4 p.M740fs and p.T792A, which was inherited from her father and mother, respectively.

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