Table 2 Differentially regulated functional pathways in GCs of FL1 compared to ctrl mice in estrus. The canonical pathway analysis is calculated based on the IPA Ingenuity Knowledge Base. Official gene symbols are sorted by the fold change, starting with the lowest Log2FC
Canonical pathway | p-value | z-score | Involved genes | |
|---|---|---|---|---|
Stronger expression | Weaker expression | |||
Gluconeogenesis | 1.73E-03 | n.a. | Gapdh, Me1 | Me2 |
Inhibition of matrix metalloproteases | 5.58E-03 | n.a. | Timp1 | Mmp11, Lrp1 |
LXR/RXR activation | 5.78E-03 | −0.5 | Pltp, Apof, Lyz | Apoa4, Agt |
Xenobiotic metabolism general signaling pathway | 1.07E-02 | 2.2 | Map3k14, Pik3c2g, Mgst2, Maf, Gsto1 | Â |
Inositol phosphate metabolism | 1.33E-02-3.53E-02 | 0.5–0.8 | Ptpn22, Ptpn22, Dusp23, Pik3c2g | Inpp5b, Sgpp2 |
Insulin receptor signaling | 4.13E-02 | 2.0 | Ppp1r14a, Pic3c2g, Sgk1 | Inpp5b |
Myo-inositol biosynthesis | 4.54E-02 | n.a. | Â | Isyna1 |