Table 3 Differentially regulated functional pathways in GCs of FL1 compared to ctrl mice in diestrus. The canonical pathway analysis is calculated based on the IPA Ingenuity Knowledge Base. Official gene symbols are sorted by the fold change, starting with the lowest Log2FC
Canonical pathway | p-value | z-score | Involved genes | |
|---|---|---|---|---|
Stronger expression | Weaker expression | |||
RAR activation | 1.03E-03 | n.a. | Smarcd3, Crabp2, Aldh1a1 | Scand1, Rpl7a, Rarg |
Inositol phosphate metabolism | 3.37E-03- 1.02E-02 | 1.0–1.3 | Inpp5d, Dusp2, Dusp23, Atp1a1 | Ephx2 |
Oxytocin signaling pathway | 2.10E-02 | 1.3 | Ptgfr, Ppara, Pla2g12a, Pla2g4a | Cacna2d1 |
Xenobiotic metabolism signaling | 2.37E-02 | n.a. | Mgst2, Hs3st1, Maf, Aldh1a1 | Scand1 |
p38 MAPK signaling | 2.99E-02 | n.a. | Pla2g12a, Pla2ga4 | Mef2d |