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Table 4 Functional annotations of differentially expressed genes of FL1 mice in estrus. The biofunctions are calculated based on the IPA Ingenuity Knowledge Base. Official gene symbols are sorted by the fold change, starting with the lowest Log2FC

From: Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1

Functional annotation

p-value

z-score

Involved genes

Stronger expression

Weaker expression

Reproductive system development and function

 Fertility

3.66E-03

2.3

F13a1, Clcf1, Kl, Pltp, Lhcgr, Timp1, Acsl4, Sfrp4, Mfge8

Inpp5b, Agt

 Litter size

1.74E-03

1.7

Oxtr, Timp1, Acsl4, Efna5, Sfrp4, Setd3, Mfge8

Etnk2

Lipid metabolism and molecular transport

 Synthesis of lipid

5.37E-07

1.0

Map 3 k4, Elovl7, Pltp, Akr1c18, Rab27a, Lhcgr, Pik3c2g, Prlr, Star, Mgst, Fdx1, Me1, Lpin1, Idh1, Acsl4, Abcb1b, Sgms2, Tspo, Hsd3b1

Me2, Serinc5, Lta4h, Apoa4, Agt, Etnk2, Hpgd, St3gal5, Grem2, Neu3, Cyp1b1, Sgpp2, Dkkl

 Transport of lipid

1.79E-05

1.1

Pcolce2, Pltp, Apof, Vnn1, Star, Lipg, Gm2a, Acsl4, Abcb1b, Nceh1, Tspo

Lrp1, Apoa4

 Transport of metal

7.19E-04

2.1

Slc11a1, Cybrd1, Kcnab3, Prlr, Sgk1, Mt2, Ndrg2, Atp1b1, Nipal1, Mt1

Necitin1, Agt, Kcnj2, Prss30, H2-Q10

 Transport of molecule

1.23E-03

1.5

Cym, Pcolce2, Ptpn22, Kl, Slc11a1, Pltp, Oxtr, Apof, Rab27a, Lhcgr, Cybrd1, Kcnab3, Prlr, Vnn1, Star, Lipg, Gm2a, Sgk1, Acsl4, Mt2, Abcb1b, Nipal1, Slc7a8, Nceh1, Sgms2, Mt1, Tspo, Ptp4a2

Lrp1, Upf1, Necitin1, Apoa4, Agt, Kdm8, Kcnj2, Prss30, H2-Q10

Cell death and survival

 Apoptosis

2.07E-04

−1.8

Clcf1, Ptpn2, Kl, Map 3 k14, Sema3f, Adamtsl4, Tub, Ifi203, Rab27a, Tnfrsf19, Lhcgr, Parvb, Lgals3, Rora, S100a4, Prlr, Vnn1, St3gal, Star, Sgk1, Eif4a1, Gapdh, Maf, Timp1, Ltbp1, Idh1, Dpp7, Acsl4, Mt2, Ethe1, Ndrg2, Sfrp4, Anxa5, Nek7, Nceh1, Sgms2, Nrp1, Mt1, Tspo, Ptp4a2, Mfge8, Pros1, Ubr4, Tcf4

Wdr5, Dynll1, Itsn1, Bcl11a, Ddit4, Lrp1

 Regeneration of cells

2.82E-04

0.7

Clcf1, Sgk1, Mt2, Mt1, Tcf4

Agt, Neu3, Kcnj2

Endocrine system development, function and disorder

 Steroid metabolism

6.89E-07

1.3

Pltp, Akr1c18, Apof, Lhcgr, Rora, Prlr, Star, Fdx1, Acsl4, Tspo, Hsd3b1

Lrp1, Apoa4, Agt, Grem2, Cyp1b1

 Metabolism of progesterone

2.89E-06

1.3

Akr1c18, Lhcgr, Prlr, Star, Acsl4, Tspo, Hsd3b1

Agt, Grem2

 Metabolism of hormone

5.12E-07

1.3

Crym, Elovl7, Akr1c18, Lhcgr, Prlr, Star, Fdx1, Acsl4, Tspo, Hsd3b1

Agt, Grem2, Cyp1b1, Dkkl

 Reduction of hormone

3.65E-03

n.a.

Akr1c18, Hsd3b1

 

 Hypogonadism

2.82E-04

n.a.

F13a1, Kl, Sema3f, Lhcgr, Prlr, St3gal1, Ltbp1

Serinc5