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Table 5 Functional annotations of differentially expressed genes of FL1 mice in diestrus. The biofunctions are calculated based on the IPA Ingenuity Knowledge Base. Official gene symbols are sorted by the fold change, starting with the lowest Log2FC

From: Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1

Functional annotation

p-value

z-score

Involved genes

Stronger expression

Weaker expression

Lipid metabolism and molecular transport

 Quantity of steriod

1.03E-03

0.9

Star, Ptgfr, Ppara, Maf, Hsd11b2, Gpm6b, Bambi, Scarb1, Angptl4, Atp1a1

Epthx, St3gal5

 Synthesis of lipid

1.03E-06

0.6

Inpp5d, Runx2, Star, Tnfsf10, Mgst2, Ppara, Pla2g12a, Rab27a, Hsd11b2, Pla2g4a, Slc6a6, Scarb1, Angptl4, Aldh1a1, Atp1a1, Ctnnb1

Me2, Ephx2, Hpgd, Neu3, Grem2, St3gal5, Il15

 Concentration of lipid

2.53E-06

2.6

Inpp5d, Star, Tnfsf10, Ptgfr, Ppara, Smarcd3, Rgcc, Rab27a, Maf, Hsd11b2, Gpm6b, Bambi, Pla2g4a, Scarb1, Angptl4, Aldh1a1, Atp1a1, Ctnnb1

Ephx2, Cacna2d1, Hpgd, Neu3, St3gal2

 Synthesis of fatty acid

3.30E-04

1.8

Tnfsf10, Mgst2, Pla2g4a, Angptl14, Aldh1a1, Ctnnb1,

Me2, Ephx2, Hpgd, Il15

 Lipolysis

4.77E-04

1.9

Inpp5d, Tnfsf10, Ppara, Gm2a, Pla2g4a, Scarb1, Angptl4

Neu3

 Hydrolysis of lipid

1.78E-04

1.6

Inpp5d, Tnfsf10, Gm2a, Pla2g4a, Scarb1, Angptl4

Neu3

Cell death and survival

 Apoptosis

5.01E-04

0.4

Cd53, Inpp5d, Atp6v0d2, Runx3, Dusp2, Runx2, Tcim, Tnfaip2, Ptprz1, Star, Tnfsf10, Ptgfr, Parvb, Ppara, Rab27a, Maf, Hsd11b2, Gpm6b, Rnase1, Mmd2, Pla2g4a, Sema7a, Crabp2, Ccng1, Slc6a6, Scarb1, Angptl4, Aldh1a1, Atp1a1, Ctnnb1

Triap1, Mef2d, Hspe1, Mrtfa, Rarg, Hpgd, Neu3, Rassf2, Gjc1, Il15, Dph7