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Fig. 1 | Journal of Ovarian Research

Fig. 1

From: LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC

Fig. 1

DANCR is decreasingly expressed in POI and DANCR knockdown induces ovarian granulosa cells aging. A, FISH staining of DANCR in human and mouse ovarian granulosa cells. B, The qPCR result of DANCR expression in granulosa cells of normal women (NOR group) and POI patients. C, Dancr expression of primary granulosa cells was qualified using qPCR in the old (32 weeks) mice and young (8 weeks) mice. D, DANCR knockdown efficiency in KGN and COV434 granulosa cell lines. SA-β-Gal staining in KGN cells (E) and COV343 cells (F), the blue indicates aging cells and the percentage of aging cells is quantified. * p < 0.05, **p < 0.01, **** p < 0.0001. Scale bar: 50 μm

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Journal of Ovarian Research

ISSN: 1757-2215

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