Skip to main content
Fig. 6 | Journal of Ovarian Research

Fig. 6

From: LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC

Fig. 6

Knockdown of DANCR promotes granulosa cells aging via regulating the interaction of hNRNPC and p53. A, SA-β-Gal assays showed the cell aging with different transfection treatments in KGN cells. Knockdown of DANCR (shDANCR group) promoted cell aging, while meanwhile overexpressed hNRNPC (OEhNRNPC + shDANCR group) could relieve cell aging. Scale bar: 50 μm. B, Protein level of p53 with different transfection treatments in KGN cells. The increased p53 expression when DANCR knockdown, was significantly reduced with overexpressed hNRNPC. shNC and OENC serve as negative control. *p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. C, A schematic graph illustrating the role of DANCR in POI. Knockdown of DANCR upregulates the p53 protein level through alleviating the binding of p53 and hNRNPC, which enhances ovarian granulosa cells aging, follicles atresia and hormone disorders, eventually casing POI development

Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us