Table 2 Clinical data of patients with identified loss-of-function variants

BRCA1

c.5266dupC

–

epithelial

serous

Gx

–

–

–

epithelial

clear cell

G₂

–

–

–

epithelial

serous

G₂

–

–

–

epithelial

serous

G₂

–

omental metastases

BRCA2

c.4043G>C

epithelial

squamous cell

G₃

cervical cancer; breast cancer

liver metastases

–

epithelial

serous

G₄

breast cancer

–

–

epithelial

serous

Gx

–

vaginal metastases

BRCA1

c.3700_3704delGTAAA

ATM c.2149C>T

epithelial

serous

G₄

–

omental and mesenteric metastases

BRCA1

c.3143delG

PALB2

c.1486G>C

epithelial

serous

G₂

–

–

–

epithelial

serous

G₂

breast cancer

lymph node metastases

BRCA1

c.4035delA

–

epithelial

serous

G₃

–

omental metastases

BRCA1

c.181 T > G

–

epithelial

mucinous

G₂/G₃

–

omental metastases

BRCA2

c.3751dupA

–

epithelial

serous

G₂

–

–

CHEK2

c.1100delC

ATM

c.6028A>G

epithelial

serous

Gx

–

–

NBN

c.429G > A

–

epithelial

serous

Gx

–

–

MSH6

c.1299 T > G

BRCA2

c.5624A>C; MUTYH c.985G>A

epithelial

mixed

G₂/G₃

endometrial cancer

–