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Fig. 6 | Journal of Ovarian Research

Fig. 6

From: Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries

Fig. 6

mir-379-5p suppresses the basal and androgen-induced rat preantral follicle growth through reduced granulosa cell proliferation in vivo. A A schematic image of experimental design and how rats received different treatments; B Histological images of ovaries which received the following treatments, lentivirus-RFP, lentivirus-RFP-mir-379-5p, DHT + lentivirus-RFP, DHT + lentivirus-RFP-mir-379-5p; C, D & E Ovarian mir-379-5p overexpression reduced ovarian growth (length and weight) in control group and suppressed granulosa cell proliferation and preantral follicle number in both control and androgenized rats. Lentivirus particles (2 μl) were injected under the ovarian bursa. The dosage and successful transduction was confirmed in Supplementary Fig. 10. *P < 0.05; **P < 0.01, ***P < 0.001

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