Table 2 Univariate and multivariate analyses of clinicopathologic parameters in elderly patients with EOC for predicting overall survival (OS)

Age at diagnosis (years)

1.040(1.034–1.046)

 < 0.001

1.040(1.034–1.046)

 < 0.001

Year of diagnosis (years)

 2000–2006

Reference

 2007–2013

0.975(0.889–1.070)

0.597

0.990(0.868–1.128)

0.876

 2014–2019

0.846(0.735–0.974)

0.020

0.942(0.776–1.143)

0.546

Race

 White

Reference

Reference

 Black

1.027(0.828–1.274)

0.809

1.161(0.934–1.444)

0.178

 Other^a

0.668(0.553–0.807)

 < 0.001

0.744(0.615–0.900)

0.002

Grade

 G1

Reference

Reference

 G2

1.654(1.314–2.057)

 < 0.001

1.285(1.023–1.615)

0.031

 G3

2.634(2.143–3.237)

 < 0.001

1.477(1.184–1.841)

0.001

 G4

2.720(2.195–3.369)

 < 0.001

1.430(1.135–1.802)

0.002

Histology

 Serous

Reference

Reference

 Mucinous

0.502(0.398–0.634)

 < 0.001

1.257(0.973–1.624)

0.080

 Endo/adeno

0.415(0.362–0.476)

 < 0.001

0.851(0.731–0.991)

0.038

 Clear cell

0.576(0.477–0.694)

 < 0.001

1.489(1.217–1.823)

 < 0.001

 Other^b

0.989(0.783–1248)

0.924

1.211 (0.955–1.535)

0.114

AJCC Stage

 I

Reference

Reference

 II

1.663(1.390–1.989)

 < 0.001

1.652(1.262–2.162)

 < 0.001

 III

3.837(3.374–4.363)

 < 0.001

2.451(1.987–3.024)

 < 0.001

 IV

5.274(4.556–6.104)

 < 0.001

3.183(2.533–4.000)

 < 0.001

SEER Stage

 Local

Reference

Reference

 Regional

1.843(1.548–2.195)

 < 0.001

1.070(0.725–1.578)

0.734

 Distant

3.892(3.411–4.441)

 < 0.001

1.136(0.822–1.570)

0.440

CA125 Pretreatment

 Negative

Reference

Reference

 Positive

1.917(1.497–2.455)

 < 0.001

1.072(0.833–1.380)

0.587

 Unknown

1.849(1.451–2.357)

 < 0.001

0.994(0.746–1.323)

0.965

Laterality

 Unilateral

Reference

Reference

 Paired

2.165(1.420–3.301)

 < 0.001

1.116(0.727–1.713)

0.616

 Bilateral

1.828(1.680–1.989)

 < 0.001

1.257(1.146–1.378)

 < 0.001

T Stage

 T1

Reference

Reference

 T2

1.765(1.478–2.107)

 < 0.001

0.949(0.727–1.239)

0.698

 T3

4.236(3.706–4.843)

 < 0.001

1.401(1.132–1.735)

0.002

 TX

2.657(2.271–3.109)

 < 0.001

1.286(1.044–1.584)

0.018

Surgery

 Pelvic exenteration

Reference

Reference

 Debulking

0.915(0.755–1.110)

0.367

1.374(0.692–2.728)

0.364

 Local resection

0.425(0.350–0.517)

 < 0.001

0.738(0.600–0.907)

0.004

 No surgery

1.676(0.850–3.304)

0.136

0.945(0.775–1.152)

0.575

Lymph node examined

0.990(0.986–0.993)

 < 0.001

0.987(0.983–0.991)

 < 0.001

Lymph node positive

1.032(1.026–1.037)

 < 0.001

1.024(1.015–1.033)

 < 0.001

Radiation

 No /unknown

Reference

 Yes

1.120(0.771–1.626)

0.552

Chemotherapy

 No /unknown

Reference

Reference

 Yes

1.171(1.060–1.293)

0.002

0.801 (0.720–0.892)

 < 0.001

Bone metastasis

 No

Reference

Reference

 Yes

5.026(2.085–12.114)

 < 0.001

2.699(1.091–6.674)

0.032

 Unknown

1.131(1.035–1.235)

0.006

1.117(1.014–1.230)

0.024

Lung metastasis

 No

Reference

Reference

 Yes

2.144(1.561–2.954)

 < 0.001

1.245(0.891–1.738)

0.199

 Unknown

1.153(1.055–1.261)

0.002

0.967(0.364–2.571)

0.946

Liver metastasis

 No

Reference

Reference

 Yes

1.699(1.237–2.334)

0.001

0.856(0.614–1.193)

0.358

 Unknown

1.152(1.053–1.259)

0.002

2.226(0.807–6.145)

0.122

Brain metastasis

 No

Reference

Reference

 Yes

9.639(2.398–38.744)

0.001

4.387(1.083–17.771)

0.038

 Unknown

1.128(1.033–1.232)

0.007

0.861(0.026–28.160)

0.933