Table 3 Univariate and multivariate analyses of characteristics for predicting cancer specific survival (CSS) in elderly patients with EOC

Age at diagnosis (years)

1.025(1.019–1.031)

 < 0.001

1.025(1.018–1.032)

 < 0.001

Year of diagnosis (years)

 2000–2006

Reference

 2007–2013

1.003(0.907–1.109)

 < 0.001

0.993(0.860–1.146)

0.924

 2014–2019

0.852(0.735–0.989)

 < 0.001

0.923(0.751–1.135)

0.449

Race

 White

Reference

Reference

 Black

1.029(0.814–1.300)

0.812

1.203(0.950–1.523)

0.125

 Other^a

0.709(0.580–0.868)

0.001

0.807(0.659–0.988)

0.038

Grade

 G1

Reference

Reference

 G2

2.292(1.702–3.087)

 < 0.001

1.653(1.221–2.237)

0.001

 G3

4.210(3.186–5.564)

 < 0.001

1.926(1.439–2.579)

 < 0.001

 G4

4.317(3.247–5.741)

 < 0.001

1.819(1.347–2.455)

 < 0.001

Histology

 Serous

Reference

Reference

 Mucinous

0.347(0.256–0.470)

 < 0.001

1.211(0.874–1.678)

0.249

 Endo/Adeno

0.280(0.235–0.334)

 < 0.001

0.694(0.574–0.839)

 < 0.001

 Clear cell

0.561(0.458–0.687)

 < 0.001

1.697(1.365–2.111)

 < 0.001

 Other

1.029(0.806–1.315)

0.816

1.287(1.003–1.650)

0.047

AJCC Stage

 I

Reference

Reference

 II

2.383(1.898–2.993)

 < 0.001

1.654(1.007–2.715)

0.047

 III

6.548(5.510–7.782)

 < 0.001

2.559(1.685–3.884)

 < 0.001

 IV

9.274(7.697–11.173)

 < 0.001

3.342(2.184–5.113)

 < 0.001

SEER Stage

 Local

Reference

Reference

 Regional

2.932(2.332–3.686)

 < 0.001

1.510(0.957–2.381)

0.077

 Distant

7.279(6.042–8.769)

 < 0.001

1.780(1.209–2.622)

0.003

CA125 Pretreatment

 Negative

Reference

Reference

 Positive

2.073(1.584–2.712)

 < 0.001

1.029(0.783–1.354)

0.836

 Other^b

1.951(1.498–2.541)

 < 0.001

0.970(0.711–1.324)

0.850

Laterality

 Unilateral

Reference

Reference

 Paired

2.508(1.627–3.865)

 < 0.001

1.300(0.837–2.018)

0.243

 Bilateral

2.033(1.855–2.227)

 < 0.001

1.234(1.118–1.361)

 < 0.001

T Stage

 T1

Reference

Reference

 T2

2.362(1.909–2.922)

 < 0.001

0.939(0.685–1.288)

0.697

 T3

6.346(5.367–7.502)

 < 0.001

1.298(0.988–1.706)

0.061

 TX

3.749(3.094–4.543)

 < 0.001

1.256(0.959–1.646)

0.098

Surgery

 Pelvic exenteration

Reference

Reference

 Debulking

0.829(0.682–1.008)

0.061

0.947(0.414–2.167)

0.897

 Local resection

0.336(0.275–0.410)

 < 0.001

0.687(0.556–0.849)

0.001

 No surgery

1.151(0.506–2.618)

0.737

0.908(0.743–1.111)

0.349

Lymph node examined

0.991(0.987–0.995)

 < 0.001

0.988(0.984–0.992)

 < 0.001

Lymph node positive

1.033(1.028–1.038)

 < 0.001

1.021(1.012–1.030)

 < 0.001

Radiation

 No /unknown

Reference

 Yes

1.203(0.817–1.772)

0.349

Chemotherapy

 No /unknown

Reference

Reference

 Yes

1.398(1.247–1.568)

 < 0.001

0.819(0.725–0.924)

0.001

Bone metastasis

 No

Reference

Reference

 Yes

5.442(2.257–13.121)

 < 0.001

2.888(1.165–7.159)

0.022

 Unknown

1.120(1.020–1.230)

0.018

1.134(1.023–1.257)

0.016

Lung metastasis

 No

Reference

Reference

 Yes

2.320(1.682–3.201)

 < 0.001

1.209(0.861–1.697)

0.273

 Unknown

1.145(1.042–1.259)

0.005

1.049(0.389–2.833)

0.924

Liver metastasis

 No

Reference

Reference

 Yes

1.836(1.331–2.533)

 < 0.001

0.853(0.608–1.197)

0.357

 Unknown

1.141(1.038–1.255)

0.006

1.699(0.565–5.111)

0.345

Brain metastasis

 No

Reference

Reference

 Yes

10.779(2.680–43.356)

0.001

4.595(1.133–18.638)

0.033

 Unknown

1.117(1.017–1.226)

0.020

0.721(0.017–30.480)

0.864