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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems

Fig. 3

The applications of 3D spheroid, organoid and co-culture models for EOC research.

Each model system can be used for a multitude of different assays or technologies to further expand our understanding of this disease. Single-cell techniques for transcriptomics or clonal evolution will be popular to determine the diverse nature of EOC. As well, co-culture models can be used to study tumours and spheroids in terms of the acellular components, cancer initiating cells, cell-matrix and cell-cell interactions. These approaches will in turn help researchers discover new targeted therapies, develop biorepositories for future research and potential predictive biomarkers for EOC patients. Created with Biorender.com

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