Fig. 2

Changes in fetal ovarian morphology are caused by prenatal prednisone exposure (PPE) with different doses or at different time. (A) Ovarian morphology (HE, 200 ×, 400 ×, n = 5, yellow arrowhead showed the oocytes, black arrow showed the ovarian pre-granulosa cells); (B, C) Maximum diameter of ovarian cross section (µm); (D, E) Number of oocytes per unit area (N/10⁴ µm²). Mean ± S.E.M., n = 5. ^*P < 0.05, ^**P < 0.01 vs. control. C1, control of PH; PL, prednisone low-dose exposure; PH, prednisone high-dose exposure; C2, control of PE; C3, control of PT; PE, prednisone early high-dose exposure; PT, prednisone terminal high-dose exposure