Fig. 6

Changes of the Hippo signaling pathway in fetal ovary induced by prenatal prednisone exposure (PPE) with different doses or at different time. (A-H) mRNA expression of MST1, MST2, YAP1and TAZ. Mean ± S.E.M., n = 12. ^**P < 0.01 vs. control. GAPDH, glyceraldehyde phosphate dehydrogenase; MST1, multiple tumor suppressor 1; MST2, multiple tumor suppressor 2; YAP1, yes-associated protein 1; TAZ, transcriptional co-Activator with PDZ-binding motif; C1, control of PH; PL, prednisone low-dose exposure; PH, prednisone high-dose exposure; C2, control of PE; PE, prednisone early high-dose exposure; C3, control of PT; PT, prednisone terminal high-dose exposure