Fig. 1

The interaction between brain and ovary through HPO axis by hormone release. Main neurotransmitter secretion in CNS that might affect the release of GnRH in hypothalamus include Glu, GABA and transmitters secreted by KNDy cells, including NKB, Kisspeptin and DYN. Brain interacts with ovary through hormones secreted from pituitary gland (FSH and LH) and from ovary (Estrogen, Progestin and inhibin). The relationship between ovary and brain can be described as HPO axis