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Table 3 Risk factors associated with anastomotic leak using a logistic regression model

From: Anastomotic leakage after resection of the rectosigmoid colon in primary ovarian cancer

 

Univariable analysis

Multivariable analysis

 

OR (95% CI)

p-value

OR (95% CI)

p-value

Age at surgery

0.999(0.967–1.032)

0.9508

  

BMI, kg/m2

    

 normal: 18.5–24.9

1(ref)

(0.7488)

  

 low < 18.5

1.584(0.456–5.505)

0.5454

  

 high ≥: 25

1.168(0.508–2.684)

0.8763

  

Histology

    

 High grade serous

1(ref)

   

 Others

0.609(0.231–1.607)

0.3166

  

Diabetes

    

 No

1(ref)

 

1(ref)

 

 Yes

3.319(1.212–9.088)

0.0196

3.788(1.130–12.693)

0.0309

Timing of cytoreductive surgery

    

 PCS

1(ref)

   

 ICS

0.998(0.474–2.103)

0.9961

  

Serum albumin level (g/dL)

    

 ≥3.0

1(ref)

   

 <3.0

3.372(1.112–10.225)

0.0318

  

ASA

    

 1

1(ref)

(0.0897)

  

 2

0.930(0.429–2.017)

0.1100

  

 3 or more

2.946(0.989–8.782)

0.0294

  

Stage (FIGO 2014)

    

 I, II

1(ref)

(0.6604)

  

 III

1.946(0.453–8.371)

0.3953

  

 IV

1.701(0.322–8.975)

0.7366

  

Cholecystectomy

    

 No

1(ref)

   

 Yes

1.376(0.553–3.422)

0.4925

  

Distal pancreatectomy

    

 No

1(ref)

 

1(ref)

 

 Yes

6.323(2.216–18.037)

0.0006

4.806(1.351–17.099)

0.0153

Splenectomy

    

 No

1(ref)

   

 Yes

1.429(0.677–3.017)

0.3496

  

Residual tumor

    

 Microscopic

1(ref)

 

1(ref)

 

 Macroscopic

7.116(3.237–15.645)

<0.0001

7.434(3.238–)

<0.0001

Additional bowel resection

    

 No

1(ref)

   

 Yes

1.348(0.571–3.183)

0.4964

  

Use of Bevacizumab

    

 No

1(ref)

   

 Yes

0.535(0.071–4.012)

0.5425

  

HIPEC

    

 No

1(ref)

   

 Yes

0.767(0.179–3.29)

0.7216

  

Protective ostomy

    

 None

1(ref)

   

 Ileostomy/colostomy

2.213(0.821–5.966)

0.1164

  

Operation time, min

1.001(0.998–1.004)

0.4469

  

Blood loss

1.002(1.000-1.003)

0.0896

  

IMA ligation (Missing = 2)

    

 No

1(ref)

   

 Yes

1.101(0.513–2.365)

0.8042

  

Anastomotic level from the anal verge (cm) (Missing = 47)

   

 ≥ 10.0

1(ref)

 

1(ref)

 

 < 10.0

5.480(1.892–15.868)

0.0017

7.008(2.291–21.434)

0.0006

  1. OR, Odds ratio; BMI, Body mass index; ASA, American Society of Anesthesiologists;
  2. FIGO, the International Federation of Gynecology and Obstetrics; HIPEC, Hyperthermic intraperitoneal chemotherapy; IMA, Inferior mesenteric artery