From: Anastomotic leakage after resection of the rectosigmoid colon in primary ovarian cancer
 | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|
 | OR (95% CI) | p-value | OR (95% CI) | p-value |
Age at surgery | 0.999(0.967–1.032) | 0.9508 |  |  |
BMI, kg/m2 | Â | Â | Â | Â |
 normal: 18.5–24.9 | 1(ref) | (0.7488) |  |  |
 low < 18.5 | 1.584(0.456–5.505) | 0.5454 |  |  |
 high ≥: 25 | 1.168(0.508–2.684) | 0.8763 |  |  |
Histology | Â | Â | Â | Â |
 High grade serous | 1(ref) |  |  |  |
 Others | 0.609(0.231–1.607) | 0.3166 |  |  |
Diabetes | Â | Â | Â | Â |
 No | 1(ref) |  | 1(ref) |  |
 Yes | 3.319(1.212–9.088) | 0.0196 | 3.788(1.130–12.693) | 0.0309 |
Timing of cytoreductive surgery | Â | Â | Â | Â |
 PCS | 1(ref) |  |  |  |
 ICS | 0.998(0.474–2.103) | 0.9961 |  |  |
Serum albumin level (g/dL) | Â | Â | Â | Â |
 ≥3.0 | 1(ref) |  |  |  |
 <3.0 | 3.372(1.112–10.225) | 0.0318 |  |  |
ASA | Â | Â | Â | Â |
 1 | 1(ref) | (0.0897) |  |  |
 2 | 0.930(0.429–2.017) | 0.1100 |  |  |
 3 or more | 2.946(0.989–8.782) | 0.0294 |  |  |
Stage (FIGO 2014) | Â | Â | Â | Â |
 I, II | 1(ref) | (0.6604) |  |  |
 III | 1.946(0.453–8.371) | 0.3953 |  |  |
 IV | 1.701(0.322–8.975) | 0.7366 |  |  |
Cholecystectomy | Â | Â | Â | Â |
 No | 1(ref) |  |  |  |
 Yes | 1.376(0.553–3.422) | 0.4925 |  |  |
Distal pancreatectomy | Â | Â | Â | Â |
 No | 1(ref) |  | 1(ref) |  |
 Yes | 6.323(2.216–18.037) | 0.0006 | 4.806(1.351–17.099) | 0.0153 |
Splenectomy | Â | Â | Â | Â |
 No | 1(ref) |  |  |  |
 Yes | 1.429(0.677–3.017) | 0.3496 |  |  |
Residual tumor | Â | Â | Â | Â |
 Microscopic | 1(ref) |  | 1(ref) |  |
 Macroscopic | 7.116(3.237–15.645) | <0.0001 | 7.434(3.238–) | <0.0001 |
Additional bowel resection | Â | Â | Â | Â |
 No | 1(ref) |  |  |  |
 Yes | 1.348(0.571–3.183) | 0.4964 |  |  |
Use of Bevacizumab | Â | Â | Â | Â |
 No | 1(ref) |  |  |  |
 Yes | 0.535(0.071–4.012) | 0.5425 |  |  |
HIPEC | Â | Â | Â | Â |
 No | 1(ref) |  |  |  |
 Yes | 0.767(0.179–3.29) | 0.7216 |  |  |
Protective ostomy | Â | Â | Â | Â |
 None | 1(ref) |  |  |  |
 Ileostomy/colostomy | 2.213(0.821–5.966) | 0.1164 |  |  |
Operation time, min | 1.001(0.998–1.004) | 0.4469 |  |  |
Blood loss | 1.002(1.000-1.003) | 0.0896 | Â | Â |
IMA ligation (Missing = 2) |  |  |  |  |
 No | 1(ref) |  |  |  |
 Yes | 1.101(0.513–2.365) | 0.8042 |  |  |
Anastomotic level from the anal verge (cm) (Missing = 47) |  |  |  | |
 ≥ 10.0 | 1(ref) |  | 1(ref) |  |
 < 10.0 | 5.480(1.892–15.868) | 0.0017 | 7.008(2.291–21.434) | 0.0006 |