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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM)

Fig. 2

Downregulation of HSPD1 promotes the proliferation ability of ovarian cancer cells. A Western blotting analysis of HSPD1 expression in SKOV3 and OVCAR3 cells transfected with NC siRNA and HSPD1 siRNA, respectively. B SKOV3 and OVCAR3 cells were transduced with lentiviruses delivering negative control shRNA (sh-NC) or HSPD1 shRNA (sh-HSPD1). Changes in HSPD1 protein expression was measured by western blotting. C Effects of HSPD1 knockdown with siRNA on the proliferation of SKOV3 analyzed by the RTCA assay. D Effects of HSPD1 knockdown with lentivirus shRNA on the proliferation of SKOV3 analyzed by the RTCA assay. E Effects of HSPD1 knockdown with siRNA on the proliferation of OVCAR3 analyzed by the RTCA assay. F Graphical representation of the concentration of glucose in cell culture medium after 72 h cell culture. G Graphical representation of the concentration of lactate in cell culture medium after 72 h cell culture. *P < 0.05, ** P < 0.01 and ***P < 0.001

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Journal of Ovarian Research

ISSN: 1757-2215

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