DOR (n = 443) | Non-DOR (n = 7736) | P value | |
---|---|---|---|
Baseline characteristics | |||
Age (y) | 31(28–34) | 30(27–32) | < 0.001* |
BMI (kg/m2) | 21.6(19.8–24.0) | 21.3(19.6–23.4) | 0.048* |
Primary infertility | 303(68.4%) | 5546(71.7%) | 0.135 |
Duration of infertility (years) | 2(1–4) | 3(2–4) | 0.004* |
AMH (ng/mL) | 0.8(0.6–1.0) | 4.1(2.6–6.3) | < 0.001* |
AFC | 6(4–8) | 13(9–17) | < 0.001* |
Infertility diagnosis | < 0.001* | ||
Female factor | 300(67.7%) | 3816(49.3%) | |
Male factor | 24(5.4%) | 1868(24.1%) | |
Female and male factors | 111(25.1%) | 1164(15.0%) | |
Unknown | 8(1.8%) | 888(11.5%) | |
Prior ovarian surgery (n) | 7(1.6%) | 96(1.2%) | 0.534 |
COS Protocol | < 0.001* | ||
GnRH agonist | 60(13.5%) | 5928(76.6%) | |
GnRH antagonist | 368(83.1%) | 1758(22.7%) | |
Others | 15(3.4%) | 50(0.6%) | |
Gn vials (days) | 9(8–10) | 10(9–11) | < 0.001* |
Total Gn dose (IU) | 2775(2400–3422) | 2250(1800–2873) | < 0.001* |
E2 | 1356 (964–1933) | 2437 (1666–3417) | < 0.001* |
P | 0.64 (0.44–0.91) | 0.81 (0.58–1.05) | < 0.001* |
Endometrial thickness | 10.9 (9.4–12.4) | 11.8 (10.3–13.5) | < 0.001* |
Fertilization methods | 0.001* | ||
IVF cycles | 324(73.1%) | 5021(64.9%) | |
ICSI cycles | 93(21.0%) | 2235(28.9%) | |
IVF + ICSI cycles | 26(5.9%) | 480(6.2%) | |
No. of oocytes retrieved | 6(4–8) | 12(9–15) | < 0.001* |
Mature oocyte rate (%) | 2335/2652(88.0%) | 80,849/93173(86.8%) | 0.056 |
Normal fertilization rate (%) | 1702/2335(72.9%) | 56,529/80849(69.9%) | 0.002* |
Blastocyst formation rate (%) | 622/986(63.1%) | 29,790/44602(66.8%) | 0.015* |
Available blastocyst rate (%) | 418/622(67.2%) | 19,574/29790(65.7%) | 0.437 |
Embryo type transferred | < 0.001* | ||
Cleavage embryo | 425 (95.9%) | 7051 (91.1%) | |
Blastocyst | 18 (4.1%) | 685 (8.9%) | |
2 embryos transferred | 162 (36.6%) | 3388 (43.8%) | 0.003* |
No. of embryo transferred | 605 | 11,124 | |
Biochemical pregnancy rate (%) | 20 (4.5%) | 393 (5.1%) | 0.597 |
Clinical pregnancy rate (%) | 212 (47.9%) | 4440 (57.4%) | < 0.001* |
Implantation rate of cleavage embryos (%) | 242/585 (41.4%) | 4974/10407 (47.8%) | 0.002* |
Implantation rate of blastocysts (%) | 10/20 (50.0%) | 423/717 (59.0%) | 0.420 |
Live birth rate (%) | 178 (40.2%) | 3866 (50.0%) | < 0.001* |
Cumulative live birth rate (%) | 230 (51.9%) | 5589 (72.2%) | < 0.001* |