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Table 1 Patients’ general characteristics and clinical outcomes

From: Diminished ovarian reserve may not be associated with a poorer fresh cycle outcome in women < 38 years

 

DOR (n = 443)

Non-DOR (n = 7736)

P value

Baseline characteristics

 Age (y)

31(28–34)

30(27–32)

 < 0.001*

 BMI (kg/m2)

21.6(19.8–24.0)

21.3(19.6–23.4)

0.048*

 Primary infertility

303(68.4%)

5546(71.7%)

0.135

 Duration of infertility (years)

2(1–4)

3(2–4)

0.004*

 AMH (ng/mL)

0.8(0.6–1.0)

4.1(2.6–6.3)

 < 0.001*

 AFC

6(4–8)

13(9–17)

 < 0.001*

Infertility diagnosis

  

 < 0.001*

 Female factor

300(67.7%)

3816(49.3%)

 

 Male factor

24(5.4%)

1868(24.1%)

 

 Female and male factors

111(25.1%)

1164(15.0%)

 

 Unknown

8(1.8%)

888(11.5%)

 

Prior ovarian surgery (n)

7(1.6%)

96(1.2%)

0.534

COS Protocol

  

 < 0.001*

 GnRH agonist

60(13.5%)

5928(76.6%)

 

 GnRH antagonist

368(83.1%)

1758(22.7%)

 

 Others

15(3.4%)

50(0.6%)

 

Gn vials (days)

9(8–10)

10(9–11)

 < 0.001*

Total Gn dose (IU)

2775(2400–3422)

2250(1800–2873)

 < 0.001*

E2

1356 (964–1933)

2437 (1666–3417)

 < 0.001*

P

0.64 (0.44–0.91)

0.81 (0.58–1.05)

 < 0.001*

Endometrial thickness

10.9 (9.4–12.4)

11.8 (10.3–13.5)

 < 0.001*

Fertilization methods

  

0.001*

 IVF cycles

324(73.1%)

5021(64.9%)

 

 ICSI cycles

93(21.0%)

2235(28.9%)

 

 IVF + ICSI cycles

26(5.9%)

480(6.2%)

 

No. of oocytes retrieved

6(4–8)

12(9–15)

 < 0.001*

Mature oocyte rate (%)

2335/2652(88.0%)

80,849/93173(86.8%)

0.056

Normal fertilization rate (%)

1702/2335(72.9%)

56,529/80849(69.9%)

0.002*

Blastocyst formation rate (%)

622/986(63.1%)

29,790/44602(66.8%)

0.015*

Available blastocyst rate (%)

418/622(67.2%)

19,574/29790(65.7%)

0.437

Embryo type transferred

  

 < 0.001*

 Cleavage embryo

425 (95.9%)

7051 (91.1%)

 

 Blastocyst

18 (4.1%)

685 (8.9%)

 

2 embryos transferred

162 (36.6%)

3388 (43.8%)

0.003*

No. of embryo transferred

605

11,124

 

Biochemical pregnancy rate (%)

20 (4.5%)

393 (5.1%)

0.597

Clinical pregnancy rate (%)

212 (47.9%)

4440 (57.4%)

 < 0.001*

Implantation rate of cleavage embryos (%)

242/585 (41.4%)

4974/10407 (47.8%)

0.002*

Implantation rate of blastocysts (%)

10/20 (50.0%)

423/717 (59.0%)

0.420

Live birth rate (%)

178 (40.2%)

3866 (50.0%)

 < 0.001*

Cumulative live birth rate (%)

230 (51.9%)

5589 (72.2%)

 < 0.001*

  1. Continuous data are reported as medians (first quartile, third quartile) and analyzed by Mann–Whitney U tests
  2. Categorical data are reported as n (%) and analyzed by χ2
  3. DOR diminished ovarian reserve, BMI body mass index, AMH anti-Müllerian hormone, AFC antral follicle count, COS controlled ovarian stimulation, Gn gonadotropin, GnRH gonadotropin-releasing hormone, E2 estradiol, P progesterone, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection
  4. *P < .05