Fig. 1
From: Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR
Sensitivity of small molecule inhibitors of OCCC cell lines with silencing of ARID1A. ARID1A isogenic OVCA429 OCCC cell lines were treated with drugs for 72 h with 2 replicates (Rep 1, Rep 2) each from KD (ARID1A shRNA knockdown) versus WTC (wildtype control). (A) The 38 small molecule inhibitors showed significantly different cytotoxicity when comparing KD to WTC. IC50 values (0–10,000 nM, Supplementary Table 2) for each inhibitor are expressed in a clustered heatmap. (B) IC50 of 18 compounds with cytotoxicity toward both KD and WTC are presented in dot plot fashion. (C) Significant differential response to 9 different combination treatment (KD vs. WTC). Red, higher IC50; Blue, lower IC50.