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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR

Fig. 5

Analysis of cell cycle and apoptosis. Analysis of OCCC cell lines treated with AZD1775 and AZD6738 (WT: ES2; Mut: KOC7C; ARID1A isogenic: ES2 WTC, ES2 KD) treated with AZD1775, AZD6738 or combination of both at IC50 for 24 h. (A) Cell cycle analysis. Stacked bar graphs show the fractions of cells at Pre-G1, G1, S or G2/M phase. (B) Apoptosis analysis. Bar graphs show the fractions of annexin V positive cells. (Two-tailed t test: *, p < 0.05 compared to control; #, p < 0.05 combination compared to single agent, n = 2). Also see Supplementary Fig. 6

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