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Fig. 7 | Journal of Ovarian Research

Fig. 7

From: A novel autophagy-related gene signature associated with prognosis and immune microenvironment in ovarian cancer

Fig. 7

FOXO1 expression is up-regulated in OV and relates to poor clinical outcomes. A Representative immunohistochemistry (IHC) staining images of FOXO1 expression of various specimens (including the normal ovary tissue, primary OV lesion, and metastatic lesion) were shown. Original magnification × 200. B Compared with normal ovary tissues and primary OV lesions, metastatic lesions had higher FOXO1 expression, measured by the Histochemistry score (H-score). C Representative IHC staining images of primary and metastatic lesions from 5 OV patients. Original magnification × 200. D Western blotting (left) and PCR analysis (right) of FOXO1 protein and mRNA expression in primary and metastatic lesions from 5 OV patients. E Analyzed through IHC staining, FOXO1 expression was increased in patients who suffered progression or death. F Upregulation of FOXO1 correlates with poor survival. Kaplan–Meier survival curves for the progression-free survival (PFS, left) and overall survival (OS, right) of 125 OV patients were shown, which were divided into subgroups based on FOXO1 expression

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