Table 1 Clinical, histologic, and molecular characteristics of UTROSCT (n = 19)
Case | Age (y) | Surgery | TS (cm) | Tumor Margins | Tumor architecture | Cyto- morphology | Necrosis | Significant nuclear atypia | Mitoses (/10HPF) | NCOA1-3 Fusion | NCOA1-3 Fusion Detection Method | JAZF1/SUZ12/ PHF1 Rearrangement | Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 31 | NA | 2.5 | Infiltrative | Sertoliform | Spindle and epithelioid | No | Yes | < 1 | ESR1-NCOA2 | RNA-Seq | Negative | NTR (18.9 m) |
2 | 35 | NA | 3 | Infiltrative | Sertoliform, corded | Spindle and epithelioid | No | No | < 1 | NA | NA | NA | NTR (40.9 m) |
3 | 51 | NA | 3 | Infiltrative | Sertoliform, nested | Spindle and epithelioid | No | No | < 1 | NA | NA | NA | NTR (43.9 m) |
4 | 41 | Yes | 5.5 | Infiltrative | Sertoliform, nested, corded | Spindle and epithelioid | No | No | 3 | ESR1-NCOA2 | RNA-Seq | Negative | Metastasis (144.4 m) |
5 | 53 | Yes | 3 | Infiltrative | Sertoliform, trabecular, retifrom | Spindle and epithelioid | No | No | 2 | GREB1-NCOA2 | RNA-Seq | Negative | NTR (44.7 m) |
6 | 33 | NA | 3 | Infiltrative | Sertoliform, corded | Spindle and epithelioid | No | No | 2 | ESR1-NCOA3 | RNA-Seq | Negative | NTR (54.9 m) |
7 | 48 | Yes | 2 | Infiltrative | Nested | Spindle and epithelioid | No | No | 2 | NA | NA | NA | NTR (56.4 m) |
8 | 44 | NA | 3 | NA | Sertoliform, corded | Spindle and epithelioid | NA | NA | NA | NA | NA | NA | NTR (62.3 m) |
9 | 46 | NA | 2.5 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | No | No | 2 | Negative | RNA-Seq | Negative | Died (26.3 m) Metastasis (2.5 m) |
10 | 19 | NA | 3 | Infiltrative | Corded, trabecular | Spindle and epithelioid | No | No | 2 | NA | NA | NA | Metastasis (69.9 n) |
*11 | 52 | Yes | 15 | Circumscribed | Corded, trabecular | Epithelioid | Yes | Yes | 8 | Negative | RNA-Seq | JAZF1-SUZ12 | NTR (14.0 m) |
12 | 58 | Yes | 4 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | No | Yes | 2 | GREB1-NCOA1 | RNA-Seq | Negative | NTR (22.6 m) |
13 | 36 | Yes | 1.5 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | Yes | Yes | 10 | Negative | RNA-Seq | Negative | Metastasis (56.5 m) |
14 | 55 | Yes | 13 | Infiltrative | Sertoliform, corded, trabecular | Spindle and epithelioid | No | Yes | 2 | GREB1-NCOA2 | RNA-Seq | Negative | Metastasis (195.3 m) |
15 | 48 | Yes | 3 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | No | Yes | < 1 | ESR1-NCOA3 | RNA-Seq | Negative | NTR (9.2 m) |
16 | 44 | No | 3 | Infiltrative | Sertoliform, corded, trabecular | Spindle and epithelioid | Yes | Yes | 2 | Negative | RNA-Seq | Negative | NTR (1.2 m) |
17 | 29 | Yes | 3 | Circumscribed | nested | Spindle and epithelioid | Yes | Yes | 8 | Negative | RNA-Seq | Negative | NTR (7.9 m) |
18 | 42 | Yes | 3.3 | Circumscribed | Sertoliform, retiform | Spindle and epithelioid | No | Yes | < 1 | NA | NA | NA | NTR (9.2 m) |
19 | 48 | Yes | 2.2 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | NA | NA | NA | NA | NA | NA | Metastasis (21.1 m) |