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  1. Content type: Research

    RNA-Seq allows a theoretically unbiased analysis of both genome-wide transcription levels and mutation status of a tumor. Using this technique we sought to identify novel candidate therapeutic targets expresse...

    Authors: Rebecca A Mosig, Li Lin, Emir Senturk, Hardik Shah, Fei Huang, Peter Schlosshauer, Samantha Cohen, Robert Fruscio, Sergio Marchini, Maurizio D'Incalci, Ravi Sachidanandam, Peter Dottino and John A Martignetti

    Citation: Journal of Ovarian Research 2012 5:4

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  2. Content type: Research

    We sought to identify candidate serum biomarkers for the detection and surveillance of EOC. Based on RNA-Seq transcriptome analysis of patient-derived tumors, highly expressed secreted proteins were identified...

    Authors: Rebecca A Mosig, Mollie Lobl, Emir Senturk, Hardik Shah, Samantha Cohen, Eugene Chudin, Robert Fruscio, Sergio Marchini, Maurizio D'Incalci, Ravi Sachidanandam, Peter Dottino and John A Martignetti

    Citation: Journal of Ovarian Research 2012 5:3

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  3. Content type: Research

    Malignant ovarian disease is characterised by high rates of mortality due to high rates of recurrent chemoresistant disease. Anecdotal evidence indicates this may be due to chemoresistant properties of cancer ...

    Authors: Michael F Gallagher, Cynthia CBB Heffron, Alexandros Laios, Sharon A O'Toole, Brendan Ffrench, Paul C Smyth, Richard J Flavin, Salah A Elbaruni, Cathy D Spillane, Cara M Martin, Orla M Sheils and John J O'Leary

    Citation: Journal of Ovarian Research 2012 5:2

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  4. Content type: Brief communication

    Some techniques of transvaginal ovarian drilling have been previously described. Nevertheless a monopolar transvaginal ovarian cauterization, that use the expertise and safety of transvaginal puncture for oocy...

    Authors: Anita M Pimentel, Danielle Kobayashi, Lucia M Kliemann, Renato Franjdlich, Edison Capp and Helena VE Corleta

    Citation: Journal of Ovarian Research 2012 5:1

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  5. Content type: Research

    Resistance to current chemotherapeutic agents is a major cause of therapy failure in ovarian cancer patients, but the exact mechanisms leading to the development of drug resistance remain unclear.

    Authors: Cheryl A Sherman-Baust, Kevin G Becker, William H Wood III, Yongqing Zhang and Patrice J Morin

    Citation: Journal of Ovarian Research 2011 4:21

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  6. Content type: Research

    Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of...

    Authors: Anna Felisiak-Golabek, Alina Rembiszewska, Iwona K Rzepecka, Lukasz Szafron, Radoslaw Madry, Magdalena Murawska, Tomasz Napiorkowski, Piotr Sobiczewski, Beata Osuch and Jolanta Kupryjanczyk

    Citation: Journal of Ovarian Research 2011 4:20

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  7. Content type: Research

    Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of childbearing age, and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current stu...

    Authors: Afshin Mohammadi, Mohammadreza Aghasi, Leila Jodeiry-farshbaf, Shaker Salary-Lac and Mohammad Ghasemi-rad

    Citation: Journal of Ovarian Research 2011 4:19

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  8. Content type: Research

    Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cell...

    Authors: Deep Agnani, Olga Camacho-Vanegas, Catalina Camacho, Shashi Lele, Kunle Odunsi, Samantha Cohen, Peter Dottino and John A Martignetti

    Citation: Journal of Ovarian Research 2011 4:18

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  9. Content type: Research

    Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive can...

    Authors: Smriti Kumar, Arooshi Kumar, Parag P Shah, Shesh N Rai, Siva K Panguluri and Sham S Kakar

    Citation: Journal of Ovarian Research 2011 4:17

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  10. Content type: Review

    The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that HOX genes are strongly expres...

    Authors: Zoë L Kelly, Agnieszka Michael, Simon Butler-Manuel, Hardev S Pandha and Richard GL Morgan

    Citation: Journal of Ovarian Research 2011 4:16

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  11. Content type: Research

    Adnexal cancers are in fifth place among the tumors with the highest mortality in the female population. The aim of the present study was to evaluate the accuracy of Multi-detector computed tomography (MDCT) o...

    Authors: Fatemeh Gatreh-Samani, Mohammad Kazem Tarzamni, Elaheh Olad-Sahebmadarek, Ali Dastranj and Aimaz Afrough

    Citation: Journal of Ovarian Research 2011 4:15

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  12. Content type: Research

    Ovarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impac...

    Authors: Marcela F Paes, Renata D Daltoé, Klesia P Madeira, Lucas CD Rezende, Gabriela M Sirtoli, Alice L Herlinger, Leticia S Souza, Luciana B Coitinho, Débora Silva, Murilo F Cerri, Ana Cristina N Chiaradia, Alex A Carvalho, Ian V Silva and Leticia BA Rangel

    Citation: Journal of Ovarian Research 2011 4:14

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  13. Content type: Case report

    The presence of oocytes in the ovarian surface epithelium has already been confirmed in the fetal ovaries. We report the presence of SSEA-4, SOX-2, VASA and ZP2-positive primitive oocyte-like cells in the adul...

    Authors: Irma Virant-Klun, Thomas Skutella, Branko Cvjeticanin, Martin Stimpfel and Jasna Sinkovec

    Citation: Journal of Ovarian Research 2011 4:13

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  14. Content type: Research

    Study of the hen immune system led to seminal contributions to basic immunological principles. Recent studies of spontaneous ovarian cancer in the laying hen show strikingly similar tumor types and antigen exp...

    Authors: Yi Yu, Seby L Edassery, Animesh Barua, Jacques S Abramowicz, Janice M Bahr, Ingegerd Hellstrom and Judith L Luborsky

    Citation: Journal of Ovarian Research 2011 4:12

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  15. Content type: Brief communication

    Endometriosis Health Profile (EHP-5) is a valid instrument to measure health-related quality of life in endometriosis. This study was conducted to culturally adapt and validate the EHP-5 in Iran.

    Authors: Azita Goshtasebi, Maryam Nematollahzadeh, Fatemeh Zahra Hariri and Ali Montazeri

    Citation: Journal of Ovarian Research 2011 4:11

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  16. Content type: Research

    Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death in the USA. Recurrence rates are high after front-line therapy and most patients eventually die from platinum (Pt) - resistant d...

    Authors: Clarisse S Muenyi, Vanessa A States, Joshua H Masters, Teresa W Fan, C William Helm and J Christopher States

    Citation: Journal of Ovarian Research 2011 4:9

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  17. Content type: Research

    Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation. Because of the significant preva...

    Authors: Mary E Sabatini, Lankai Guo, Maureen P Lynch, Joseph O Doyle, HoJoon Lee, Bo R Rueda and Aaron K Styer

    Citation: Journal of Ovarian Research 2011 4:8

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  18. Content type: Research

    Recent evidence has suggested that the capability of cancer to grow, propagate and relapse after therapy is dependent on a small subset of the cell population within the tumor, called cancer stem cells. Theref...

    Authors: Moorthy P Ponnusamy, Parthasarathy Seshacharyulu, ArokiaPriyanka Vaz, Parama Dey and Surinder K Batra

    Citation: Journal of Ovarian Research 2011 4:7

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  19. Content type: Research

    In the search for unique ovarian cancer biomarkers, ovarian specific cDNA microarray analysis identified hRad17, a cell cycle checkpoint protein, as over-expressed in ovarian cancer. The aim of this study was ...

    Authors: Jennifer L Young, E Colin Koon, Joseph Kwong, William R Welch, Michael G Muto, Ross S Berkowitz and Samuel C Mok

    Citation: Journal of Ovarian Research 2011 4:6

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  20. Content type: Case report

    Malignant transformation is a rare complication of mature cystic teratoma with squamous cell carcinoma being the most common type. We report a new case of squamous cell carcinoma in situ.

    Authors: Fatima A Zakkouri, Saloua Ouaouch, Saber Boutayeb, Mouna Rimani, Lamiae Gamra, Hind Mrabti and Hassan Errihani

    Citation: Journal of Ovarian Research 2011 4:5

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  21. Content type: Research

    Sphingosine-1 receptor 1 (S1P1) plays a major role in regulating lymphocyte egress from peripheral lymph tissue. Lymphocyte trafficking is potentially a critical response to tumors and to tumor vaccines. Also,...

    Authors: Michael J Bradaric, Animesh Barua, Krishna Penumatsa, Yu Yi, Seby L Edassery, Sameer Sharma, Jacques S Abramowicz, Janice M Bahr and Judith L Luborsky

    Citation: Journal of Ovarian Research 2011 4:4

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  22. Content type: Research

    The prostaglandin D2 (PGD2) pathway is involved in numerous biological processes and while it has been identified as a partner of the embryonic sex determining male cascade, the roles it plays in ovarian funct...

    Authors: Andalib Farhat, Pascal Philibert, Charles Sultan, Francis Poulat and Brigitte Boizet-Bonhoure

    Citation: Journal of Ovarian Research 2011 4:3

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  23. Content type: Research

    Blood flow in the corpus luteum (CL) is closely related to luteal function. It is unclear how luteal blood flow is regulated. Standardized ovarian-stimulation protocol with a gonadotropin-releasing hormone ago...

    Authors: Akihisa Takasaki, Isao Tamura, Fumie Kizuka, Lifa Lee, Ryo Maekawa, Hiromi Asada, Toshiaki Taketani, Hiroshi Tamura, Katsunori Shimamura, Hitoshi Morioka and Norihiro Sugino

    Citation: Journal of Ovarian Research 2011 4:2

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  24. Content type: Research

    We showed there are specific ALDH1 autoantibodies in ovarian autoimmune disease and ovarian cancer, suggesting a role for ALDH1 in ovarian pathology. However, there is little information on the ovarian express...

    Authors: Krishna Penumatsa, Seby L Edassery, Animesh Barua, Michael J Bradaric and Judith L Luborsky

    Citation: Journal of Ovarian Research 2010 3:28

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  25. Content type: Research

    Ovarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In recent years, infrared (IR) spectroscopy has gained attention as a simple and inexp...

    Authors: Ranjana Mehrotra, Gunjan Tyagi, Deepak K Jangir, Ramesh Dawar and Noopur Gupta

    Citation: Journal of Ovarian Research 2010 3:27

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  26. Content type: Research

    To verify the feasibility of ovarian stromal evaluation and correlate ovarian parameteres (echogenicity and volume) with hyperandrogenism, and both cardiovascular and metabolic risk factors in PCOS.

    Authors: Giuseppe Loverro, Giovanni De Pergola, Edoardo Di Naro, Massimo Tartagni, Cristina Lavopa and Anna Maria Caringella

    Citation: Journal of Ovarian Research 2010 3:25

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  27. Content type: Research

    Most cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity. The objective of this study was to establish an immunocomp...

    Authors: Bridget A Quinn, Fang Xiao, Laura Bickel, Lainie Martin, Xiang Hua, Andres Klein-Szanto and Denise C Connolly

    Citation: Journal of Ovarian Research 2010 3:24

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  28. Content type: Research

    Given the high rate of pregnancy and perinatal complications recently observed in patients with polycystic ovary syndrome (PCOS) and the lack of data on the serum variations in androgens and insulin sensitivit...

    Authors: Angela Falbo, Morena Rocca, Tiziana Russo, Antonietta D'Ettore, Achille Tolino, Fulvio Zullo, Francesco Orio and Stefano Palomba

    Citation: Journal of Ovarian Research 2010 3:23

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  29. Content type: Research

    New biomarkers that replace or are used in conjunction with the current ovarian cancer diagnostic antigen, CA125, are needed for detection of ovarian cancer in the presurgical setting, as well as for detection...

    Authors: John D Andersen, Kristin LM Boylan, Ronald Jemmerson, Melissa A Geller, Benjamin Misemer, Katherine M Harrington, Starchild Weivoda, Bruce A Witthuhn, Peter Argenta, Rachel Isaksson Vogel and Amy PN Skubitz

    Citation: Journal of Ovarian Research 2010 3:21

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  30. Content type: Research

    chA21 is a novel tumor-inhibitory antibody which recognized subdomain I of HER2 extracellular domain with an epitope distinct from other HER2 antibodies. Previously, we demonstrated that chA21 inhibits human o...

    Authors: Anli Zhang, Guodong Shen, Ting Zhao, Guihong Zhang, Jing Liu, Lihua Song, Wei Wei, Ling Bing, Zhengsheng Wu and Qiang Wu

    Citation: Journal of Ovarian Research 2010 3:20

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  31. Content type: Review

    This review describes the use of polymer micelle nanotechnology based chemotherapies for ovarian cancer. While various chemotherapeutic agents can be utilized to improve the survival rate of patients with ovar...

    Authors: Murali M Yallapu, Meena Jaggi and Subhash C Chauhan

    Citation: Journal of Ovarian Research 2010 3:19

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  32. Content type: Case report

    The association of pseudo-Meigs' syndrome, elevation of CA 125 to the struma ovarii is a rare condition. So far only nine cases have been reported in English literature through MEDLINE search. Here we report a...

    Authors: Wei Jiang, Xin Lu, Zhi Ling Zhu, Xi Shi Liu and Cong Jian Xu

    Citation: Journal of Ovarian Research 2010 3:18

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  33. Content type: Research

    In view of the recent association of Brn-3 transcription factors with neuroblastomas, cervical, breast, and prostate cancers we examined the expression of Brn-3a(l) in normal ovaries and in different histologi...

    Authors: Nuzhat Ahmed, Ardian Latifi, Clyde B Riley, Jock K Findlay and Michael A Quinn

    Citation: Journal of Ovarian Research 2010 3:17

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  34. Content type: Research

    No data regarding metformin effects on follicular fluid anti-Müllerian hormone (AMH) levels were to date available in literature. The aim of the present study was to evaluate in patients with polycystic ovary ...

    Authors: Angela Falbo, Morena Rocca, Tiziana Russo, Antonietta D'Ettore, Achille Tolino, Fulvio Zullo, Francesco Orio and Stefano Palomba

    Citation: Journal of Ovarian Research 2010 3:16

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  35. Content type: Research

    Cisplatin is more often used to treat ovarian cancer (OvCa), which provides modest survival advantage primarily due to chemo-resistance and up regulated anti-apoptotic machineries in OvCa cells. Therefore, tar...

    Authors: Erica L Johnson, Rajesh Singh, Crystal M Johnson-Holiday, William E Grizzle, Edward E Partridge, James W Lillard Jr and Shailesh Singh

    Citation: Journal of Ovarian Research 2010 3:15

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  36. Content type: Research

    Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains...

    Authors: Björn Nodin, Nooreldin Zendehrokh, Jenny Brändstedt, Elise Nilsson, Jonas Manjer, Donal J Brennan and Karin Jirström

    Citation: Journal of Ovarian Research 2010 3:14

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  37. Content type: Research

    Mesenchymal Progenitor/Stem Cells (MSC) respond to homing cues providing an important mechanism to deliver therapeutics to sites of injury and tumors. This property has been confirmed by many investigators, ho...

    Authors: Svetlana Komarova, Justin Roth, Ronald Alvarez, David T Curiel and Larisa Pereboeva

    Citation: Journal of Ovarian Research 2010 3:12

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  38. Content type: Research

    Chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The efficacy of current treatments may be improved by increasing the sensitivity of cancer cells to chemo/radiation therapies. Cu...

    Authors: Murali M Yallapu, Diane M Maher, Vasudha Sundram, Maria C Bell, Meena Jaggi and Subhash C Chauhan

    Citation: Journal of Ovarian Research 2010 3:11

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  39. Content type: Research

    Noscapine, an alkaloid from Papaver somniferum, widely used as an antitussive, is being clinically studied in the treatment of polycystic ovary syndrome (PCOS) and a few other cancers primarily because of its ant...

    Authors: Anjali Priyadarshani, Krishna Chuttani, Gaurav Mittal and Aseem Bhatnagar

    Citation: Journal of Ovarian Research 2010 3:10

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  40. Content type: Research

    Ovarian carcinoma is the fourth most common cause of death from cancer in women. Limited progress has been made toward improving the survival rate of patients with this disease in part because of the lack of a...

    Authors: Allison C Sharrow, Brigitte M Ronnett, Christopher J Thoburn, James P Barber, Robert L Giuntoli II, Deborah K Armstrong, Richard J Jones and Allan D Hess

    Citation: Journal of Ovarian Research 2010 3:9

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  41. Content type: Review

    Ovarian cancer is particularly insidious in nature. Its ability to go undetected until late stages coupled with its non-descript signs and symptoms make it the seventh leading cause of cancer related deaths in...

    Authors: Jennifer AA Gubbels, Nick Claussen, Arvinder K Kapur, Joseph P Connor and Manish S Patankar

    Citation: Journal of Ovarian Research 2010 3:8

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  42. Content type: Research

    Ovarian follicle development is a complex process. Paracrine interactions between somatic and germ cells are critical for normal follicular development and oocyte maturation. Studies have suggested that the he...

    Authors: Jin-Yi Jiang, Huiling Xiong, Mingju Cao, Xuhua Xia, Marc-Andre Sirard and Benjamin K Tsang

    Citation: Journal of Ovarian Research 2010 3:6

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  43. Content type: Research

    Activation of bone morphogenetic protein (BMP)4 signalling in human ovarian cancer cells induces a number of phenotypic changes in vitro, including altered cell morphology, adhesion, motility and invasion, relati...

    Authors: Trevor G Shepherd, Michelle L Mujoomdar and Mark W Nachtigal

    Citation: Journal of Ovarian Research 2010 3:5

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  44. Content type: Research

    The Foxl2 transcription factor is required for ovarian function during follicular development. The mechanism of Foxl2 regulation of this process has not been elucidated. Our approach to begin to understand Fox...

    Authors: Jean M Escudero, Jodi L Haller, Colin M Clay and Kenneth W Escudero

    Citation: Journal of Ovarian Research 2010 3:4

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