From: Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics
 | A1847 | IGROV-1 | OVCAR-7 | SKOV-3 | ||||
---|---|---|---|---|---|---|---|---|
 | Parental | T100 | Parental | T100 | Parental | T100 | Parental | T100 |
Gefitinib | Â | Â | Â | Â | Â | Â | Â | Â |
0 μM | 1.000 ± 0.055 | 1.000 ± 0.008 | 1.000 ± 0.017 | 1.000 ± 0.057 | 1.000 ± 0.010 | 1.000 ± 0.034 | 1.000 ± 0.008 | 1.000 ± 0.002 |
1 μM | 0.812 ± 0.006 | 0.829 ± 0.040 | 0.998 ± 0.039 | 0.691 ± 0.026 | 0.977 ± 0.125 | 0.899 ± 0.060 | 0.797 ± 0.060 | 0.884 ± 0.022 |
 | p = 0.001 | p = 0.0005 | p = 0.93 | p = 0.0006 | p = 0.96 | p = 0.02 | p = 0.001 | p = 0.0002 |
Erlotinib | Â | Â | Â | Â | Â | Â | Â | Â |
0 μM | 1.000 ± 0.075 | 1.000 ± 0.011 | 1.000 ± 0.041 | 1.000 ± 0.037 | 1.000 ± 0.072 | 1.000 ± 0.013 | 1.000 ± 0.027 | 1.000 ± 0.043 |
1 μM | 0.741 ± 0.063 | 0.676 ± 0.053 | 0.753 ± 0.060 | 0.588 ± 0.046 | 0.612 ± 0.027 | 0.653 ± 0.096 | 0.625 ± 0.031 | 0.696 ± 0.023 |
 | p = 0.0004 | p < 10-4 | p = 0.001 | p < 10-6 | p = 0.0007 | p = 0.001 | p = 10-6 | p < 10-27 |
Lapatinib | Â | Â | Â | Â | Â | Â | Â | Â |
0 μM | 1.000 ± 0.007 | 1.000 ± 0.027 | 1.000 ± 0.048 | 1.000 ± 0.062 | 1.000 ± 0.070 | 1.000 ± 0.023 | 1.000 ± 0.108 | 1.000 ± 0.047 |
1 μM | 0.762 ± 0.063 | 0.645 ± 0.069 | 0.789 ± 0.098 | 0.666 ± 0.031 | 0.819 ± 0.084 | 0.673 ± 0.048 | 0.845 ± 0.023 | 0.889 ± 0.082 |
 | p = 0.001 | p = 0.0001 | p = 0.005 | p < 10-4 | p = 0.006 | p < 10-5 | p = 0.03 | p = 0.04 |
Cetuximab | Â | Â | Â | Â | Â | Â | Â | Â |
0 μg/ml | 1.000 ± 0.091 | 1.000 ± 0.038 | 1.000 ± 0.075 | 1.000 ± 0.067 | 1.000 ± 0.090 | 1.000 ± 0.032 | 1.000 ± 0.031 | 1.000 ± 0.049 |
200 μg/ml | 0.974 ± 0.027 | 0.594 ± 0.110 | 0.892 ± 0.071 | 0.554 ± 0.067 | 0.588 ± 0.050 | 0.657 ± 0.057 | 0.736 ± 0.038 | 0.854 ± 0.010 |
 | p = 0.57 | p = 0.0006 | p = 0.07 | p < 10-5 | p < 10-4 | p < 10-4 | p < 10-5 | p = 0.002 |
H3.105 | Â | Â | Â | Â | Â | Â | Â | Â |
0 μg/ml | 1.000 ± 0.071 | 1.000 ± 0.022 | 1.000 ± 0.050 | 1.000 ± 0.050 | 1.000 ± 0.011 | 1.000 ± 0.028 | 1.000 ± 0.040 | 1.000 ± 0.018 |
10 μg/ml | 0.913 ± 0.095 | 0.989 ± 0.059 | 1.006 ± 0.132 | 0.979 ± 0.152 | 0.895 ± 0.030 | 0.856 ± 0.027 | 0.969 ± 0.039 | 1.048 ± 0.043 |
 | p = 0.14 | p = 0.71 | p = 0.92 | p = 0.78 | p = 0.0006 | p < 10-4 | p = 0.28 | p = 0.07 |