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  1. Research

    Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells

    Ovarian cancer is the leading cause of death for gynecological cancers and the 6th cause of women cancer death in developed countries. The late stage detection, the peritoneal dissemination and the acquisition...

    Benoît Thibault and Bertrand Jean-Claude

    Journal of Ovarian Research 2017 10:31

    Published on: 26 April 2017

  2. Case report

    Serum and peritoneal fluid concentrations of soluble human leukocyte antigen, tumor necrosis factor alpha and interleukin 10 in patients with selected ovarian pathologies

    Although immune system plays a key role in the pathogenesis of both endometriosis and ovarian cancer, its function is different. Therefore, we hypothesized, that selected immune parameters can serve as diagnos...

    Olimpia Sipak-Szmigiel, Piotr Włodarski, Elżbieta Ronin-Walknowska, Andrzej Niedzielski, Beata Karakiewicz, Sylwia Słuczanowska-Głąbowska, Maria Laszczyńska and Witold Malinowski

    Journal of Ovarian Research 2017 10:25

    Published on: 4 April 2017

  3. Research

    Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

    Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been im...

    Man Xiao, Jing Cai, Liqiong Cai, Jinghui Jia, Lisha Xie, Ying Zhu, Bangxing Huang, Dongdong Jin and Zehua Wang

    Journal of Ovarian Research 2017 10:24

    Published on: 4 April 2017

  4. Research

    Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

    Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.

    Renée T. Fortner, Allison F. Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N. Fichorova, Titilayo Fashemi, Hidemi S. Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou…

    Journal of Ovarian Research 2017 10:20

    Published on: 20 March 2017

  5. Research

    Reliability of preoperative evaluation of postmenopausal ovarian tumors

    Preoperative evaluation of ovarian tumors is challenging. This study was undertaken to evaluate the performance of conventional two-dimensional (2D) ultrasound and CA125 in predicting malignant or benign natur...

    Riikka Johanna Niemi, Sami Kristian Saarelainen, Tiina Hannele Luukkaala and Johanna Unelma Mäenpää

    Journal of Ovarian Research 2017 10:15

    Published on: 14 March 2017

  6. Research

    Anatomical organization and neural pathways of the ovarian plexus nerve in rats

    In this work, a detailed anatomical description of the ovarian plexus nerve (OPN) in rats is presented. The distribution of the OPN was analyzed by gross anatomy; the features of the superior mesenteric gangli...

    César F. Pastelín, Nora H. Rosas, Leticia Morales-Ledesma, Rosa Linares, Roberto Domínguez and Carolina Morán

    Journal of Ovarian Research 2017 10:18

    Published on: 14 March 2017

  7. Review

    The role of Notch signalling in ovarian angiogenesis

    In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corp...

    Qi Xie, Zuowang Cheng, Xiaocui Chen, Corrinne G. Lobe and Ju Liu

    Journal of Ovarian Research 2017 10:13

    Published on: 11 March 2017

  8. Research

    Putative stem cells and epithelial-mesenchymal transition revealed in sections of ovarian tumor in patients with serous ovarian carcinoma using immunohistochemistry for vimentin and pluripotency-related markers

    The mechanism of aggressive character of ovarian cancer and unsuccessful treatment of women with this deadly disease has been recently explained by the theory of cancer stem cells (CSCs). It has been reported ...

    Natasa Kenda Suster, Spela Smrkolj and Irma Virant-Klun

    Journal of Ovarian Research 2017 10:11

    Published on: 23 February 2017

  9. Research

    Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population

    MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated the effects of sex hormones and obesity on...

    Weixi Xiong, Ying Lin, Lili Xu, Amin Tamadon, Shien Zou, Fubo Tian, Ruijin Shao, Xin Li and Yi Feng

    Journal of Ovarian Research 2017 10:10

    Published on: 13 February 2017

  10. Research

    Naturally occurring anti-glycan antibodies binding to Globo H-expressing cells identify ovarian cancer patients

    Glycosphingolipids are important compounds of the plasma membrane of mammalian cells and a number of them have been associated with malignant transformation and progression, reinforcing tumour aggressiveness a...

    Tatiana Pochechueva, Shahidul Alam, Andreas Schötzau, Alexander Chinarev, Nicolai V. Bovin, Neville F. Hacker, Francis Jacob and Viola Heinzelmann-Schwarz

    Journal of Ovarian Research 2017 10:8

    Published on: 10 February 2017

  11. Research

    Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy

    It has long been appreciated that different subtypes (serous, clear cell, endometrioid and mucinous) of epithelial ovarian carcinoma (EOC) have distinct pathogenetic pathways. However, clinical management, esp...

    Mengjiao Li, Haoran Li, Fei Liu, Rui Bi, Xiaoyu Tu, Lihua Chen, Shuang Ye and Xi Cheng

    Journal of Ovarian Research 2017 10:9

    Published on: 10 February 2017

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