High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer

Table 7 Cox regression analyses of overall survival

			Univariate
		HR	95% CI	*p-value*
HE4	≥405 vs. <405 pM	1.9	1.1 - 3.5	0.028
CA125	≥398 vs. <398 U/ml	2.2	1.2 - 3.8	0.006
Age	continous variable	1.02	1.003 - 1.045	0.025
Stage	2-4 vs. 1	3.3	1.6 - 6.9	0.002
Grade	3 vs. 1-2	2.5	1.4 - 4.4	0.002
Residual tumor	≥1 vs. <0-1 cm	2.9	1.8 - 4.8	<0.001
Pre-operative known parameters		Multivariate Stepvise Backward*
		HR	95% CI	*p-value*
HE4	≥405 vs. <405 pM	2.02	1.1 - 3.8	0.02
CA125	≥398 vs. <398 U/ml			ns
Age	continous variable			ns

*Multivariate Stepvise Backward conditional analyses, removal at 0.1 including HE4 and CA125 (dichotomized at median) and age (continous variable).

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