Biomarker | Positive cases | Description | Target class | Therapeutics |
---|---|---|---|---|
CCNE1 Amp | N=4 | Cyclin E1 | Cell cycle inhibitor | BMS-387032, flavopiridol, seliciclib, P1446A-05 |
ERBB2 Amp | N=1 | HER2 | Kinase | Lapatinib, trastuzumab, neratinib |
KRAS Amp | N=1 | v-Ki-ras2 | Kinase | PD 0325901, GSK1120212, AS703026, MSC1936369B, AZD6244, ARRY-438162 |
BRCA1 Del | N=7 | Early onset breast cancer gene 1 | Poly ADP Ribose Polymerase inhibitors (PARP) | AZD2281, ABT-888, MK4827 |
BRCA2 Del | N=3 | Early onset breast cancer gene 2 | Poly ADP Ribose Polymerase inhibitors (PARP) | AZD2281, ABT-888, MK4827 |
Bi-allelic PTEN Del | N=1 | Â | PI3K\AKT\mTOR inhibitors | Rapamycin |