Epithelial ovarian cancer | The ROC criteria | VEGF | HE4 | CA125 | VEGF + HE4 | VEGF + CA 125 | HE4 + CA125 | VEGF + HE4+ CA125 |
---|---|---|---|---|---|---|---|---|
I stage | AUC | 0.7984* | 0.7284* | 0.7652* | 0.8632* | 0.8784* | 0.8327* | 0.8980* |
SE | 0.0562 | 0.0708 | 0.0416 | 0.0508 | 0.0475 | 0.0538 | 0.0433 | |
95% C.I. | 0.688-0.909 | 0.590-0.867 | 0.691-0.794 | 0.764-0.963 | 0.785-0.971 | 0.727-0.938 | 0.813-0.83 | |
p AUC = 0.5 | <0.001 | 0.0013 | 0.0005 | <0.001 | <0.001 | <0.001 | <0.001 | |
II stage | AUC | 0.7231* | 0.7646* | 0.8652* | 0.8592* | 0.8587* | 0.9207* | 0.9207* |
SE | 0.0647 | 0.0562 | 0.0389 | 0.0421 | 0.0510 | 0.0314 | 0.0294 | |
95% C.I. | 0.596-0.850 | 0.654-0.875 | 0.814-0.967 | 0.777-0.942 | 0.759-0.959 | 0.859-0.982 | 0.863-0.978 | |
p AUC = 0.5 | 0.0006 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
III stage | AUC | 0.9012* | 0.9256* | 0.9112* | 0.9680* | 0.9665* | 0.9763* | 0.9837* |
SE | 0.0428 | 0.0291 | 0.0428 | 0.0167 | 0.0221 | 0.0302 | 0.0120 | |
95% C.I. | 0.817-0.985 | 0.869-0.983 | 0.827-0.995 | 0.935-1.001 | 0.923-1.010 | 0.902-1.020 | 0.960-1.007 | |
p AUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
IV stage | AUC | 0.7168* | 0.9124* | 0.9472* | 0.9240* | 0.9494* | 0.9420* | 0.9600* |
SE | 0.0722 | 0.0428 | 0.0260 | 0.0382 | 0.0315 | 0.0353 | 0.0281 | |
95% C.I. | 0.575-0.858 | 0.829-0.996 | 0.896-0.998 | 0.849-0.999 | 0.888-1.011 | 0.873-1.011 | 0.905-1.015 | |
p AUC = 0.5 | 0.0027 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
Total group | AUC | 0.7843* | 0.8321* | 0.9276* | 0.9032* | 0.9127* | 0.9180* | 0.9404* |
SE | 0.0376 | 0.0321 | 0.0221 | 0.0239 | 0.0250 | 0.0223 | 0.0187 | |
95% C.I. | 0.711-0.858 | 0.769-0.895 | 0.884-0.971 | 0.856-0.950 | 0.864-0.962 | 0.874-0.962 | 0.904-0.977 | |
p AUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
Serous epithelial | AUC | 0.7522* | 0.8720* | 0.9047* | 0.9124* | 0.9009* | 0.9391* | 0.9395* |
SE | 0.0482 | 0.0347 | 0.0301 | 0.0278 | 0.0312 | 0.0233 | 0.0230 | |
95% C.I. | 0.658-0.847 | 0.804-0.964 | 0.846-0.964 | 0.858-0.967 | 0.840-0.962 | 0.893-0.985 | 0.894-0.985 | |
p AUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
Endome-trioid epithelial | AUC | 0.8226* | 0.7843* | 0.9128* | 0.8922* | 0.9268* | 0.8926* | 0.9414* |
SE | 0.0438 | 0.0467 | 0.0305 | 0.0323 | 0.0299 | 0.0330 | 0.0228 | |
95% C.I. | 0.737-0.908 | 0.693-0.876 | 0.853-0.973 | 0.829-0.955 | 0.868-0.985 | 0.828-0.957 | 0.897-0.986 | |
p AUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |