Figure 4

COX-2 expression in the corpus luteum of pregnant rats of the control, hypothyroid and hyperthyroid groups at 10, 14 and 19 days of gestation. A) Immunohistochemical images of COX-2 expression (Streptavidin-biotin-peroxidase, Harris hematoxylin, scale bar = 12 μm). B and C) Reduction of the area and intensity of COX-2 expression in the corpus luteum of hypothyroid group compared to the control group at 10 and 19 days of gestation. The hyperthyroid group had an increase of the area and intensity of COX-2 expression in the corpus luteum compared to the control group at 19 days of gestation.