Table 3 List of molecular pathways containing genes with activated (↑) and repressed (↓) level of mRNA in DHT treated compared to CTL rat ovary groups
Biosynthesis of steroids | ↓ CYP51, ↓HMGCR, ↓SQLE, ↓HSD17B7, ↓FDFT1, ↓LSS, MVD, ↓FDPS, ↓IDI1, ↓SC5DL, ↓EBP, ↓SC4MOL, ↓TM7SF2, ↓DHCR24, ↓NSDHL |
TGF-beta signaling pathway | ↑INHBB, ↑INHBA, ↑AMH, ↑BMP2, ↑FOXO1, ↑FOXP2, ↓FKBP1A,↑ INHA, ↑ BAMBI, ↑CITED1, ↓CITED2 |
Leukocyte transendothelial migration | ↑CXCL12, ↓THY1, ↓BCAR1, ↓PECAM1,↓ CXCR4, ↑CLDN11, ↑MYL9, ↓SIPA1 |
Cholesterol biosynthesis | ↓MVD, ↓HMGCR, ↓HMGCS1, ↓FDPS, ↓IDI1, ↓FDFT1 |
Pyruvate metabolism | ↓ME1, ↓DLAT, ↑ALDH1B1, ↓ME2, ↓ACAT2, ↓ACSS2, ↑ME3 |
Glycerophospholipid metabolism | ↓PLA2G1B, ↑PLA2G2A, ↓GPD1, ↓CDS1,↓ PCYT2, ↑ETNK2, ↑CRLS1 |
Complement and coagulation cascades | ↓A2M, ↓C2, ↓PLAU, ↑TFPI, ↑MASP1,↓ CFB, ↓C1QA |
Glycolysis/Gluconeogenesis | ↓HK1, ↓HK2, ↓DLAT, ↑FBP2, ↑ALDH1B1,↓ACSS2 |
Adipocytokine signaling pathway | ↑JAK2, ↓NFKBIB, ↑IRS3, ↓ACSL3, ↓ADIPOR, ↑STK11 |
Butanoate metabolism | ↓HMGCS1, ↓AACS, ↑ALDH1B1, ↓ACAT2, ↑ACSM5 |
Terpenoid biosynthesis | ↓SQLE, ↓FDFT1, ↓FDPS, ↓IDI1 |
Ether lipid metabolism | ↓PLA2G1B, ↑PLA2G2A, ↑PAFAH1B3, ↑ENPP6 |
Citrate cycle (TCA cycle) | ↓ACLY, ↓IDH1, ↓DLAT, ↓DLST |
Androgen and estrogen metabolism | ↑SRD5A1, ↓ HSD17B1, ↓HSD17B7, ↓HSD3B6 |
Androgen/estrogene/progesterone biosynthesis | ↓HSD3B6, ↓CYP11A1, ↓NSDHL, ↓CYP19A1 |
Glutathione metabolism | ↓GPX1, ↓IDH1, ↓GSTT1, ↑GPX7 |
Lysine degradation | ↑ALDH1B1, ↓DLST, ↓ACAT2, ↑MGC109340 |
Fatty acid metabolism | ↑ACSL3, ↓ACAA2, ↑ALDH1B1, ↓ACAT2 |
Valine, leucine and isoleucine degradation | ↓HMGCS1, ↓ACAA2, ↑ALDH1B1, ↓ACAT2 |