Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

Table 4 Discriminatory ability of ovarian cancer biomarkers adjusted for predictors of those biomarkers among women postmenopausal at blood collection: EPIC

	Time Between Blood Collection and Diagnosis
	<1 year	1–2 years	2–3 years	>3 years
CA125
biomarker	0.86 (0.79–0.92)	0.78 (0.71–0.84)	0.61 (0.51–0.70)	0.57 (0.54–0.61)
adjusted biomarker ^a	0.85 (0.79–0.92)	0.78 (0.72–0.85)	0.60 (0.51–0.70)	0.57 (0.54–0.61)
CA15.3
biomarker	0.66 (0.57–0.75)	0.60 (0.52–0.68)	0.61 (0.52–0.70)	0.56 (0.52–0.59)
adjusted biomarker ^a	0.67 (0.57–0.76)	0.60 (0.52–0.68)	0.61 (0.52–0.70)	0.56 (0.52–0.59)
HE4
biomarker	0.84 (0.77–0.90)	0.68 (0.61–0.76)	0.61 (0.52–0.70)	^b
adjusted biomarker ^a	0.84 (0.77–0.90)	0.70 (0.62–0.77)	0.62 (0.52–0.71)	^b
CA72.4
biomarker	0.76 (0.69–0.84)	0.67 (0.59–0.75)	0.61 (0.51–0.70)	^b
adjusted biomarker ^a	^c	^c	^c	^b
All biomarkers				CA125 and CA15.3^b
biomarker	0.87 (0.81–0.93)	0.79 (0.73–0.85)	0.60 (0.51–0.70)	0.57 (0.54–0.61)
adjusted biomarker ^a	0.89 (0.84–0.95)	0.80 (0.73–0.86)	0.62 (0.53–0.71)	0.57 (0.54–0.61)

^aBiomarker residuals accounting for significant predictors: CA125: parity, hysterectomy, unilateral oophorectomy, age at menopause, E only HT, ovulatory cycles, current smoking; CA15.3: BMI, former smoking; HE4: age at blood draw, OC use, parity, age at menopause, current smoking; CA72.4: none; ^bHE4 and CA72.4 only measured in cases diagnosed within 3 years of blood collection; ^cNo predictors identified

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